Abstract
Were synthesized hybrids nanoparticles consisting of an iron oxide nucleus and coatings of Gum Arabic (GA) and gold nanoparticles. Taking advantage of the GA, it has the function of stabilizing the iron oxide nanoparticles and protecting the surface from oxidation. Also, they have the function of reducing metals such as gold; so, in situ synthesis of gold nanoparticles was carried out to obtain the hybrid composed of iron oxide nanoparticles with GA and gold. The aim is to take advantage of the photothermal (PTT) properties of gold and the magnetic properties of iron oxide to obtain a material that works for a dual therapy: photothermal and magnetic hyperthermia (MHT) for cancer treatment. The structural, morphological, and magnetic characterization of the hybrid nanoparticles was obtained. The presence of gold nanoparticles was confirmed by X-ray diffraction: the hybrid diffraction patterns show the peaks corresponding to the NP–Au; also, the TEM images show a crystal size of 12 nm. The colloidal stability increment with the presence of gold nanoparticles obtained a zeta potential value of 21 mV. The magnetization saturation for hybrids was 47 emu/g and a blocking temperature was 336 K. These results manifest that MNP–GA–Au could be a promising alternative for dual treatment, PTT and MHT for cancer treatment.
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Acknowledgements
The Authors would like to thank Guanajuato University for the partial support in this research under Grant DAIP-2021/59023 and Ma. Lourdes Palma Tirado of INB-UNAM Campus Juriquilla for his support in the processing of images by TEM.
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Guzmán-Rocha, D., Córdova-Fraga, T., Bernal-Alvarado, J. et al. Hybrid nanoparticles consisting of magnetic iron oxide and gold nanoparticles modified with Arabic gum. MRS Advances 7, 5–11 (2022). https://doi.org/10.1557/s43580-021-00195-x
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DOI: https://doi.org/10.1557/s43580-021-00195-x