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Curcumin nanoparticles impregnated collagen/demineralized bone matrix/olive leaves extract biocomposites as a potential bone implant: Preparation, characterization, and biocompatibility

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Abstract

In this study, nanoceramic composite (NCC) was developed using the Type I collagen (COLL), demineralized bone matrix (DBM), olive leaves extract (OLE), and curcumin nanoparticles (Cu-NPs). The study evaluates the possibility of using this NCC as a bone tissue engineering material. The developed NCC was characterized by its mechanical, physicochemical, and biocompatibility properties. The NCC possessed excellent mechanical properties. A biocompatibility study was proved in the MG-63 osteoblast cell line on NCC. The study introduced a method for producing a functionalized implant, such as bone tissue engineering material, using natural resources. In vitro bone healing abilities of NCC were demonstrated in our investigation. As a result, NCC could be suggested as a source of bone graft and healing agents.

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Acknowledgments

The award of TUBITAK 2232-International Fellowship for Outstanding Researcher (Project No. 118C350) to Dr. Rethinam Senthil is gratefully acknowledged.

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Authors and Affiliations

  1. Leather Engineering Department, Engineering Faculty, Ege University, Bornova, 35100, Izmir, Turkey

    Rethinam Senthil & Aslan Ahmed

  2. School of Bio & Chemical Engineering, Sathyabama University, Chennai, Tamil Nadu, 600 199, India

    Rethinam Senthil

  3. Department of Pharmacology, Saveetha Dental College, Chennai, Tamil Nadu, 600 077, India

    Rethinam Senthil & Thangavelu Lakshmi

  4. School of Electrical Engineering and Centre for Automation, VIT Chennai Campus, Chennai, Tamil Nadu, 600 127, India

    Sivakumar Sumathi

  5. Institute of Research and Development, Duy Tan University, Da Nang, 254, Vietnam

    Ponnurengam Malliappan Sivakumar

  6. Chemistry Department, Science Faculty, Ege University, Bornova, 35100, Izmir, Turkey

    Serdar Batıkan Kavukcu

Authors
  1. Rethinam Senthil
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  2. Sivakumar Sumathi
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  3. Ponnurengam Malliappan Sivakumar
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  4. Serdar Batıkan Kavukcu
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  5. Thangavelu Lakshmi
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  6. Aslan Ahmed
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Correspondence to Rethinam Senthil.

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Senthil, R., Sumathi, S., Sivakumar, P.M. et al. Curcumin nanoparticles impregnated collagen/demineralized bone matrix/olive leaves extract biocomposites as a potential bone implant: Preparation, characterization, and biocompatibility. MRS Communications 13, 136–142 (2023). https://doi.org/10.1557/s43579-023-00324-7

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