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Nanohybrid carbon nanodots-CuFe2O4 as selectively magnetofluorescent agent on tumor cells

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Abstract

The magnetic material with carbon nanodots as magnetofluorescent multi-agents was an effective way to determine cellular information in clinical diagnosis systems. However, exploring hyaluronic acid (HA) on magnetofluorescent is limited in combining with CuFe2O4. The present study reports a new design contrast agent as a hybrid carbon nanodots (CNDs–CuFe2O4–HA) by combining the fluorescence carbon nanodots (CNDs) and copper ferrite (CuFe2O4) nanoparticles capsulated with HA. The as-prepared nanohybrid confirmed the unique properties through some important analytical techniques. The photoluminescence data showed an average diameter of the nanohybrid of about 104 nm and exhibited blue emission (λem = 420 nm). The hybrid also showed the superparamagnetic behavior and saturated magnetization (Ms) value of 0.63 emug−1, which increased the positive contrast on T1-weight relaxation of MRI as well as its specific targeting to the tumor assessed by confocal microscopy. The effective nanohybrid particles also described remarkable fluorescence and non-toxicity features that are useful for clinical diagnosis information.

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Acknowledgments

The authors thank Universitas Airlangga for research facilities and the Ministry of Research, Technology and Higher Education, Republic of Indonesia, for financial support under PPKI contract No. 304/UN3.14/PT/2020.

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Authors and Affiliations

  1. Department of Chemistry, Universitas Airlangga, Surabaya, 60115, Indonesia

    Mochamad Z. Fahmi, Denika L. N. Wibowo, Yu-yu Aung, Nindayu Indrasari & Satya C. W. Sakti

  2. Department of Chemistry, Sepuluh Nopermber Institut of Technology, Surabaya, 60111, Indonesia

    Yatim L. Nikmah

  3. Department of Physics, IPB University, Bogor, 16680, Indonesia

    Irzaman Irzaman

  4. Department of Physics, Faculty of Science, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia

    Che A. C. Abdullah

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  1. Mochamad Z. Fahmi
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Fahmi, M.Z., Wibowo, D.L.N., Aung, Yy. et al. Nanohybrid carbon nanodots-CuFe2O4 as selectively magnetofluorescent agent on tumor cells. Journal of Materials Research 38, 3416–3428 (2023). https://doi.org/10.1557/s43578-023-01066-x

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