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Preparation and properties of W/O emulsion bacteriostatic microcapsules loaded with KDF

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Abstract

Potassium diformate (KDF) has broad prospects in replacing common antibiotics in animal feed; however, the utilization rate of KDF in the animal intestine is low. Therefore, it is necessary to construct a drug delivery system for its targeted release in the colon. When Zeolite P was used as a drug-binding effector, KDF was uniformly dispersed in the pectin matrix, and the pectin bacteriostatic microspheres loaded with KDF were prepared using the emulsion cross-linking method. The optimized pectin bacteriostatic microspheres were systematically characterized, we observed that the drug loading rate and stability of pectin bacteriostatic microspheres improved significantly after adding Zeolite P and the utilization rate of KDF in the simulated intestine was higher than that in the stomach. The pectin bacteriostatic microspheres exerted significant bacteriostatic effect on Escherichia coli and Staphylococcus aureus, indicating that they may be widely used in livestock feed as bacteriostatic agents.

Graphical Abstract

In order to improve the antibacterial effect of KDF in intestinal tract, W/O emulsion microcapsules were prepared by emulsification method. When Zeolite P was used as a drug-binding effector, KDF was uniformly dispersed in the pectin matrix, and the pectin bacteriostatic microspheres loaded with KDF were prepared using the emulsion cross-linking method. Moreover, the bacteriostatic microspheres possessed significant growth inhibitory effects on E. coli, S. aureus and Bacillus subtilis.

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Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.

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Funding

National Natural Science Foundation of China, 51564008, Xiaonan Zhang, 51978189, Xiaonan Zhang

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Authors and Affiliations

  1. School of Materials Science and Engineering, Guilin University of Technology, Guilin, 541004, China

    XiaoNan Zhang, Zhongxin Yang, Wenqin Xu, Xing Li, Guanghua Pan & Nan-Chun Chen

  2. School of Environmental Science and Engineering, Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area, Guilin University of Technology, Guilin, 541006, China

    Qing-Lin Xie

  3. School of Chemical and Biological Engineering, Guilin University of Technology, Guilin, 541006, China

    Xiu Li Wang

  4. Collaborative Innovation Center for Exploration of Nonferrous Metal Deposits and Efficient Utilization of Resources, Guilin University of Technology, Guilin, China

    Nan-Chun Chen

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  1. XiaoNan Zhang
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Contributions

XZ: conceptualization, methodology, investigation, visualization, software, writing – original draft, writing—review & editing. ZY: data curation, writing—review & editing. WX: formal analysis, writing—review & editing. XL: software, writing—review & editing. GP: software, writing—review & editing. NC: supervision, project administration, funding acquisition. QX: visualization, writing—review & editing. XW: validation, writing—review & editing.

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Correspondence to Nan-Chun Chen.

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Zhang, X., Yang, Z., Xu, W. et al. Preparation and properties of W/O emulsion bacteriostatic microcapsules loaded with KDF. Journal of Materials Research 38, 2863–2873 (2023). https://doi.org/10.1557/s43578-023-01029-2

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