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Polylactide microparticles stabilized by chitosan graft-copolymer as building blocks for scaffold fabrication via surface-selective laser sintering

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Abstract

Surface-selective laser sintering (SSLS) is a specific version of selective laser sintering, which allows one to fabricate 3D structures with well-defined architectonic via selective melting of microparticle surface without alteration of their core. This mode of laser sintering requires a well-designed surface properties of the microparticles to adsorb laser irradiation. Water was chosen as safer sensitive absorber of laser radiation with a wavelength of 1.9 μm, i.e. one with low absorption coefficient by polymeric core. Biodegradable polylactide microparticles were fabricated via oil/water emulsion solvent evaporation technique using tailored-made chitosan-based macromolecules, which provided the effective interface stabilization during the microparticle fabrication and well balanced microparticle surface hydrophilicity to adsorb water. Especially build SSLS set-up was designed in order to monitor the effectiveness of the 3D scaffold fabrication from the obtained microparticles and to adapt the optimal laser radiation parameters with a wavelength of 1.9 μm (e.g. speed, line density, power).

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Funding

This research was funded by Grant (MK-1974.2019.3) of the President of the Russian Federation (in a part of development and optimization of the microparticles), Russian Foundation for Basic Research (18-32-20184, experimental setup for SSLS), Ministry of Science and Higher Education within the State assignment FSRC “Crystallography and Photonics” RAS (development of new laser additive technologies). The authors thank the University of Liège (Belgium), Wallonie-Bruxelles International (WBI) and Sechenov University (Russia) for the financial support of researcher’s mobility in a frame of this Russian-Belgian collaboration. This work was performed as part of State Task no. 0082-2019-0012.

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Authors and Affiliations

  1. Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, 8-2 Trubetskaya st., Moscow, Russia, 119991

    T. S. Demina & P. S. Timashev

  2. Enikolopov Institute of Synthetic Polymeric Materials RAS, 70 Profsoyuznaya st., Moscow, Russia, 117393

    T. S. Demina, T. N. Popyrina & T. A. Akopova

  3. Institute of Photon Technologies, Federal Scientific Research Centre “Crystallography and Photonics” RAS, 2 Pionerskaya st., Troitsk, Moscow, Russia, 108840

    E. D. Minaeva, A. A. Dulyasova, S. A. Minaeva, V. I. Yusupov, N. V. Minaev & P. S. Timashev

  4. National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), 31 Kashirskoe hwy, Moscow, Russia, 115409

    E. D. Minaeva & A. A. Dulyasova

  5. Interfaculty Research Centre On Biomaterials (CEIB), Chemistry Institute, University of Liège, B6C, Sart-Tilman, 4000, Liege, Belgium

    R. Tilkin & C. Grandfils

  6. Department of Polymers and Composites, N.N. Semenov Institute of Chemical Physics, 4 Kosygin st., Moscow, Russia, 119991

    P. S. Timashev

  7. Chemistry Department, Lomonosov Moscow State University, Leninskiye Gory 1‑3, Moscow, Russia, 119991

    P. S. Timashev

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  1. T. S. Demina
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  2. T. N. Popyrina
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  3. E. D. Minaeva
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  4. A. A. Dulyasova
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  5. S. A. Minaeva
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  6. R. Tilkin
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  7. V. I. Yusupov
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  8. C. Grandfils
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  9. T. A. Akopova
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  10. N. V. Minaev
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  11. P. S. Timashev
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Correspondence to T. S. Demina.

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Demina, T.S., Popyrina, T.N., Minaeva, E.D. et al. Polylactide microparticles stabilized by chitosan graft-copolymer as building blocks for scaffold fabrication via surface-selective laser sintering. Journal of Materials Research 37, 933–942 (2022). https://doi.org/10.1557/s43578-022-00498-1

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  • DOI: https://doi.org/10.1557/s43578-022-00498-1

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