Abstract
Polyaryletherketones (PAEK) have been hitherto the most promising high-performance semicrystalline thermoplastic polymers (HPPs) for several biomedical applications. These polymers make a competent replacement to implantable metals due to their biocompatibility, osteointegration properties, substantial bond strength, pliability, radiolucency and a comparable bone-like flexural modulus. Lately, additive manufacturing (AM) of customized 3D-printed patient-specific implants (PSI) using rapid prototyping techniques has been used for several surgical and medical implantations. Also, rapid technological progresses viz., fused deposition modelling and selective laser sintering in consort with enhanced imaging know-hows have streamlined the critical glitches of conventional HPPs processability with directing them to manufacture medically proficient 3D-PSI. Thus, PAEK and its polymers could not only be tailored into end-use implantable medical devices but also fit into newer AM technology-mediated biomedical arenas for other unexplored HPPs. This review summarizes the till date research on 3D-printed PAEK implant technology and its potential possibilities for their modernization and expansion in diverse musculoskeletal and soft tissue applications.
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References
I. Casanellas, A. García-Lizarribar, A. Lagunas, J. Samitier, Front. Bioeng. Biotechnol. 6, 128 (2018). https://doi.org/10.3389/fbioe.2018.00128
U. Nöth, L. Rackwitz, A.F. Steinert, R.S. Tuan, Adv. Drug. Deliv. Rev. 62, 765–783 (2010). https://doi.org/10.1016/j.addr.2010.04.004
P. Buckle, Occup. Med. 55, 164–167 (2005). https://doi.org/10.1093/occmed/kqi081
S. Sampson, M. Gerhardt, B. Mandelbaum, Curr. Rev. Musculoskelet. Med. 1, 165–174 (2008). https://doi.org/10.1007/s12178-008-9032-5
B.D. Smith, D.A. Grande, Nat. Rev. Rheumatol. 11, 213 (2015). https://doi.org/10.1038/nrrheum.2015.27
P. Shende, H. Gupta, R.S. Gaud, Biomed. Pharmacother. 97, 38–44 (2018). https://doi.org/10.1016/j.biopha.2017.10.127
O. Seror, Diagn. Interv Imaging 96, 617–624 (2015). https://doi.org/10.1016/j.diii.2015.04.007
T. Gonzalez-Fernandez, P. Sikorski, J.K. Leach, Acta. Biomater. 96, 20–34 (2019). https://doi.org/10.1016/j.actbio.2019.07.014
N.C. Geurs, P.J. Vassilopoulos, M.S. Reddy, Oral Maxillofac. Surg. Clin. 22, 387–405 (2010). https://doi.org/10.1016/j.coms.2010.04.001
C. Hu, D. Ashok, D.R. Nisbet, V. Gautam, Biomaterials 219, 119366 (2019). https://doi.org/10.1016/j.biomaterials.2019.119366
E. Witsø, L. Hoang, K. Løseth, K. Bergh, J. Orthop. Res. 15, 23 (2020). https://doi.org/10.1186/s13018-020-1546-6
A. Keirouz, M. Chung, J. Kwon, G. Fortunato, N. Radacsi, Interdiscip. Rev. Nanomed. Nanobiotechnol. 12, 4 (2020). https://doi.org/10.1002/wnan.1626
P. Szymczyk-Ziółkowska, M.B. Łabowska, J. Detyna, I. Michalak, P. Gruber, Biocybern. Biomed. Eng. 40, 624–638 (2020). https://doi.org/10.1016/j.bbe.2020.01.015
S. Agarwal, S. Saha, V.K. Balla, A. Pal, A. Barui, S. Bodhak, Front. Mech. Eng. 6, 90 (2020). https://doi.org/10.3389/fmech.2020.589171
A. Das, C.A. Chatham, J.J. Fallon, C.E. Zawaski, E.L. Gilmer, C.B. Williams, M.J. Bortner, Addit. Manuf. (2020). https://doi.org/10.1016/j.addma.2020.101218
B. Prabhu, M. Dadsetan, S. Bodhak, A. Karau, M. Knebel, R. Lizio, S. von Karsa-Wilberforce, U.S. Patent 2021/0008252 A1 (2021)
C. Yan, Y. Shi, L. Hao, Int. Polym. Proc. 26, 416–423 (2011). https://doi.org/10.3139/217.2452
M. Rinaldi, T. Ghidini, F. Cecchini, A. Brandao, F. Nanni, Composite B 145, 162–172 (2018). https://doi.org/10.1016/j.compositesb.2018.03.029
C.J. Hawker, F. Chu, Macromolecules 29, 4370–4380 (1996). https://doi.org/10.1021/ma9516706
V.L. Rao, J. Macromol. Sci. 35, 661–712 (1995). https://doi.org/10.1080/15321799508021753
J. Pu, C. McIlroy, A. Jones, I. Ashcroft, Addit. Manuf. 37, 101673 (2021). https://doi.org/10.1016/j.addma.2020.101673
R.M. Cowie, A. Briscoe, J. Fisher, L.M. Jennings, Proc. Inst. Mech. Eng. H 98B, 100 (2016). https://doi.org/10.1177/0954411916667410
M. Vaezi, S. Yang, Virtual Phys. Prototype 10, 123–135 (2015). https://doi.org/10.1080/17452759.2015.1097053
S.M. Kurtz, J. Nevelos, in PEEK Biomaterials Handbook 2nd edition, ed. by S. Kurtz (William Andrews Publishing, Elsevier, 2019), p. 403. https://doi.org/10.1016/B978-0-12-812524-3.00001-6
A. Mohammed, A. Elshaer, P. Sareh, M. Elsayed, H. Hassanin, Int. J. Pharm. 580, 119245 (2020). https://doi.org/10.1016/j.ijpharm.2020.119245
J. Long, H. Gholizadeh, J. Lu, C. Bunt, A. Seyfoddin, Curr. Pharm. Des 23, 433–439 (2017)
K. Cho, D. Kim, S. Yoon, Macromolecules 36, 7652–7660 (2003). https://doi.org/10.1021/ma034597p
D. Shukla, Y.S. Negi, J.S. Uppadhyaya, V. Kumar, Polym. Rev. 52, 189–228 (2012). https://doi.org/10.1080/15583724.2012.668151
R.N. Johnson, A.G. Farnham, R.A. Clendinning, W.F. Hale, C.N. Merriam, J. Polym. Sci. Part A 5, 2375–2398 (1967). https://doi.org/10.1002/pol.1967.150050916
https://www.victrex.com/en/products/polymers/peek-polymers Accessed 1 Jan 2021
W. Risse, D.Y. Sogah, F.P. Boettcher, Makromolekulare Chemie. Macromol. Symp. 44, 185–193 (1991). https://doi.org/10.1002/masy.19910440119
L. Martineau, F. Chabert, B. Boniface, G. Bernhart, Int. J. Adhes. Adhes. 89, 82–87 (2019). https://doi.org/10.1016/j.ijadhadh.2018.11.013
C. Yang, X. Tian, D. Li, Y. Cao, F. Zhao, C. Shi, J. Mater. Process. Technol. 248, 1–7 (2017). https://doi.org/10.1016/j.jmatprotec.2017.04.027
M. Yuan, J.A. Galloway, R.J. Hoffman, S. Bhatt, Polym. Eng. Sci. 51, 94–102 (2011). https://doi.org/10.1002/pen.21785
I.V. Panayotov, V. Orti, F. Cuisinier, J. Yachouh, J. Mater. Sci. Mater. Med. 27, 1–11 (2016). https://doi.org/10.1007/s10856-016-5731-4
M. Kotthaus, I. Hasan, L. Keilig, M. Grüner, C. Bourauel, H. Stark, Biomed. Tech. (Berl) 64, 555–562 (2019). https://doi.org/10.1515/bmt-2018-0167
S. Tekin, S. Cangül, O. Adıgüzel, Y. Değer, Int. J. Dent. Res. 8, 84–92 (2018). https://doi.org/10.5577/intdentres.2018.vol8.no2.6
M.S. Jahan, B.M. Walters, T. Riahinasab, R. Gnawali, D. Adhikari, H. Trieu, Radiat. Phys. Chem. 118, 96–101 (2016). https://doi.org/10.1016/j.radphyschem.2015.06.024
F. Alam, K.M. Varadarajan, J.H. Koo, B.L. Wardle, S. Kumar, Adv. Eng. Mater. 22, 2000483 (2020). https://doi.org/10.1002/adem.202000483
P.R. Monich, B. Henriques, A.P.N. de Oliveira, J.C. Souza, M.C. Fredel, Mater. Lett. 185, 593–597 (2016). https://doi.org/10.1016/j.matlet.2016.09.005
R.S. Brum, P.R. Monich, F. Berti, M.C. Fredel, L.M. Porto, C.A. Benfatti, J.C. Souza, Mater. Chem. Phys. 223, 542–547 (2019). https://doi.org/10.1016/j.matchemphys.2018.11.027
G. Skirbutis, A. Dzingutė, V. Masiliūnaitė, G. Šulcaitė, J. Žilinskas, Stomatologija 19, 19–23 (2017)
H. Alqurashi, Z. Khurshid, S.A.U. Yaqin, S.R. Habib, D. Rokaya, M.S. Zafar, J. Adv. Res. (2020). https://doi.org/10.1016/j.jare.2020.09.004
R. Singh, G. Singh, J. Singh, R. Kumar, J. Thermoplast. Compos. Mater. (2019). https://doi.org/10.1177/0892705719870595
T. Yabutsuka, K. Fukushima, T. Hiruta, S. Takai, T. Yao, Mater. Sci. Eng. C 81, 349–358 (2017). https://doi.org/10.1016/j.msec.2017.07.017
L. Wang, S. He, X. Wu, S. Liang, Z. Mu, J. Wei, F. Deng, Y. Deng, S. Wei, Biomaterials 35, 6758–6775 (2014). https://doi.org/10.1016/j.biomaterials.2014.04.085
M. Wang, G. Bhardwaj, T.J. Webster, Int. J. Nanomed. 12, 6471 (2017). https://doi.org/10.2147/IJN.S134983
Y. Li, D. Wang, W. Qin, H. Jia, Y. Wu, J. Ma, B. Tang, J. Biomater. Sci. Polym. Ed. 30, 1709–1724 (2019). https://doi.org/10.1080/09205063.2019.1659711
J.M. Toth, in Plastic Design Library 2nd edition), ed. by Steven M. Kurtz (William Andrew Publishers, Elsevier Inc., 2019), p. 107. https://doi.org/10.1016/B978-0-12-812524-3.00008-9
T. Krätzig, K.C. Mende, M. Mohme, H. Kniep, M. Dreimann, M. Stangenberg, M. Westphal, T. Gauer, S.O. Eicker, Neurosurg. Rev. 1, 1–8. (2020). https://doi.org/10.1007/s10143-020-01384-2
K.B. Sagomonyants, M.L. Jarman-Smith, J.N. Devine, M.S. Aronow, G.A. Gronowicz, Biomaterials 29, 1563–1572 (2008). https://doi.org/10.1016/j.biomaterials.2007.12.001
T.A. Kumar, J.B. Jei, B. Muthukumar, J. Indian Prosthodont. Soc. 17, 167 (2017). https://doi.org/10.4103/jips.jips_166_16
M. Peron, J. Torgersen, F. Berto, Materials 11, 19–23 (2018). https://doi.org/10.3390/ma11101923
V. Shanmugam, O. Das, K. Babu, U. Marimuthu, A. Veerasimman, D.J. Johnson, R.E. Neisiany, M.S. Hedenqvist, S. Ramakrishna, F. Berto, Int. J. Fatigue 143, 106007 (2021). https://doi.org/10.1016/j.ijfatigue.2020.106007
R. Shrestha, J. Simsiriwong, N. Shamsaei, R.D. Moser, Int J Fatigue 82, 411–427 (2016). https://doi.org/10.1016/j.ijfatigue.2015.08.022
L. Safai, J.S. Cuellar, G. Smit, A.A. Zadpoor, Addit. Manuf. 28, 87–97 (2019). https://doi.org/10.1016/j.addma.2019.03.023
M. Vaezi, S. Yang, Virtual Phys. Prototyp. 10, 123–135 (2015). https://doi.org/10.1080/17452759.2015.1097053
U.M. Dilberoglu, B. Gharehpapagh, U. Yaman, M. Dolen Procedia. Manuf. 11, 545–554 (2017). https://doi.org/10.1016/j.promfg.2017.07.148
A. Fotouh, J.D. Wolodko, M.G. Lipsett, Composite B 62, 175–182 (2014). https://doi.org/10.1016/j.compositesb.2014.02.023
N. Abbasnezhad, A. Khavandi, J. Fitoussi, H. Arabi, M. Shirinbayan, A. Tcharkhtchi, Int. J. Fatigue 109, 83–92 (2018). https://doi.org/10.1016/j.ijfatigue.2017.12.010
A.D. Pertuz, S. Díaz-Cardona, O.A. Gonźalez-Estrada, Int. J. Fatigue 130, 105–275 (2020). https://doi.org/10.1016/j.ijfatigue.2019.105275
B. Yuan, Q. Cheng, R. Zhao, X. Zhu, X. Yang, X. Yang, K. Zhang, Y. Song, X. Zhang, Biomaterials 170, 116–126 (2018). https://doi.org/10.1016/j.biomaterials.2018.04.014
P. Honigmann, N. Sharma, B. Okolo, U. Popp, B. Msallem, F.M. Thieringer, BioMed Res. Int. (2018). https://doi.org/10.1155/2018/4520636
T. Sathies, P. Senthil, M.S. Anoop, Rapid Prototyp. J. 26, 669–687 (2020). https://doi.org/10.1108/RPJ-08-2018-0199
M. Schmidt, D. Pohle, T. Rechtenwald, C.I.R.P. Ann, Manuf. Technol. 56, 205–208 (2007). https://doi.org/10.1016/j.cirp.2007.05.097
I. Peko, I. Špar, A. Bašić, In Conference Proceedings, International Conference Mechanical Technologies and Structural Materials 113 (2016)
A.C de Leon, Q. Chen, N.B. Palaganas, J.O. Palaganas, J. Manapat, R.C. Advincula, React. Funct. Polym. 103, 141–155. (2016). https://doi.org/10.1016/j.reactfunctpolym.2016.04.010
C.L. Brockett, G. John, S. Williams, Z. Jin, G.H. Isaac, J. Fisher, J. Biomed. Mater. Res. B 100, 1459–1465 (2012). https://doi.org/10.1002/jbm.b.32664
Y.S. Pan, J. Wang, J, C.L. Pan, Appl. Mech. Mater. 325–326, 3–7. (2013). https://doi.org/10.4028/www.scientific.net/AMM.325-326.3
F. Zhao, D. Li, Z. Jin, Materials 11, 288 (2018). https://doi.org/10.3390/ma11020288
C.R. Deckard, U.S. Patent 4,863,538 (1989).
C. Reiff, F. Wulle, O. Riedel, S. Epple, V. Onuseit, V, In Proceedings of the 8th International Conference on Mass Customization and Personalization 23, 230 (2014)
R. Ma, T. Tang, Int. J. Mol. Sci. 15, 5426–5445 (2014). https://doi.org/10.3390/ijms15045426
M. Vaezi, C. Black, D.M. Gibbs, R.O. Oreffo, M. Brady, M. Moshrefi-Torbati, S. Yang, Molecules 21, 687 (2016). https://doi.org/10.3390/molecules21060687
R. Bogue, Assem. Autom. 33, 307–311 (2013). https://doi.org/10.1108/AA-06-2013-055
C. von Wilmowsky, E. Vairaktaris, D. Pohle, T. Rechtenwald, R. Lutz, H. Münstedt, G. Koller, M. Schmidt, F.W. Neukam, K.A. Schlegel, E. Nkenke, J. Biomed. Mater. Res. A 87, 896–902 (2008). https://doi.org/10.1002/jbm.a.31822
W. Wu, P. Geng, G. Li, D. Zhao, H. Zhang, J. Zhao, Mater. 8, 5834–5846 (2015). https://doi.org/10.3390/ma8095271
M. Somireddy, A. Czekanski, Mater. Des. 195, 108953 (2020). https://doi.org/10.1016/j.matdes.2020.108953
F. Ning, W. Cong, J. Qiu, J. Wei, S. Wang, Composites 80, 369–378 (2015). https://doi.org/10.1016/j.compositesb.2015.06.013
F.M. Thieringer, N. Sharma, A. Mootien, R. Schumacher, P. Honigmann, in International Conference on Additive Manufacturing in Products and Applications (Springer, Cham, 2017, pp. 308–315). https://doi.org/https://doi.org/10.1007/978-3-319-66866-6_29
C.P. Kelly, A.J. Cohen, R. Yavuzer, I.T. Jackson, J. Craniofac. Surg. 16, 181–185 (2005)
M.M. Hanasono, N. Goel, F. DeMonte, Ann. Plast. Surg. 62, 653–655 (2009). https://doi.org/10.1097/SAP.0b013e318184abc7
M.M. Kim, K.D. Boahene, P.J. Byrne, Arch. Facial Plast. Surg. 11, 53–7 (2009). https://doi.org/10.1001/archfaci.11.1.53
P. Scolozzi, A. Martinez, B. Jaques, J. Craniofac. Surg. 18, 224–228 (2007). https://doi.org/10.1097/01.scs.0000249359.56417.7e
F. Jalbert, S. Boetto, F. Nadon, F. Lauwers, E. Schmidt, R. Lopez, J. Cranio. Maxillo. Fac. Surg. 42, 141–148 (2014). https://doi.org/10.1016/j.jcms.2013.04.001
S.E.C.M. van de Vijfeijken, R. Schreurs, L. Dubois, A.G. Becking, L.H.E. Karssemakers, D.M.J. Milstein, P.R.A.M. Depauw, F.W.A. Hoefnagels, W.P. Vandertop, C.J. Kleverlaan, T.J.A.G. Münker, J. Craniomaxillofac. Surg. 47, 542–547 (2019). https://doi.org/10.1016/j.jcms.2018.07.012
B. Lethaus, M.P. Ter Laak, P. Laeven, M. Beerens, D. Koper, J. Poukens, P. Kessler, J. Craniomaxillofac. Surg. 39, 435–440 (2011). https://doi.org/10.1016/j.jcms.2010.10.003
B. Lethaus, Y. Safi, M. ter Laak-Poort, A. Kloss-Brandstätter, F. Banki, C. Robbenmenke, U. Steinseifer, P. Kessler, J. Neurotrauma. 29, 1077–1083 (2012). https://doi.org/10.1089/neu.2011.1794
E.B. O’Reilly, S. Barnett, C. Madden, B. Welch, B. Mickey, S. Rozen, J. Plast. Reconstr. Aesthet. Surg. 68, 329–338 (2015). https://doi.org/10.1016/j.bjps.2014.11.001
J.R. Sarot, C.M. Contar, A.C. Cruz, R. de Souza Magini, J. Mater. Sci. Mater. Med. 21, 2079–85 (2010). https://doi.org/10.1007/s10856-010-4084-7
A.D. Schwitalla, M. Abou-Emara, T. Spintig, J. Lackmann, W.D. Muller, J. Biomech. 48, 1–7 (2015). https://doi.org/10.1016/j.jbiomech.2014.11.017
A. Schwitalla, W.D. Muller, Eur. J. Oral Implantol. 39, 743–749 (2013). https://doi.org/10.1563/AAID-JOI-D-11-00002
F. Sun, X. Shen, N. Zhou, Y. Gao, Y. Guo, X. Yang, J. Prosthet. Dent. (2019). https://doi.org/10.1016/j.prosdent.2019.10.020
J. Choi, E. Song, J. Shin, T. Jeong, J. Huh, Materials 10, 1410 (2017). https://doi.org/10.3390/ma10121410
S. Papadiochou, A.L. Pissiotis, J. Prosthet. Dent. 119, 545–551 (2018). https://doi.org/10.1016/j.prosdent.2017.07.001
H.A. Mously, M. Finkelman, R. Zandparsa, H. Hirayam, J Prosthet. Dent. 112, 249–256 (2014). https://doi.org/10.1016/j.prosdent.2014.03.017
D.J. Hak, C. Mauffrey, D. Seligson, B. Lindeque, Orthopedics 37, 825–830 (2014). https://doi.org/10.3928/01477447-20141124-05
R.K. Ponnappan, H. Serhan, B. Zarda, R. Patel, T. Albert, A.R. Vaccaro, Spine J. 9, 263–267 (2009). https://doi.org/10.1016/j.spinee.2008.08.002
M. Kyomoto, T. Moro, S. Yamane, K. Watanabe, Y. Takatori, S. Tanaka, K. Ishihara, Reconstr. Surg. 4, 150 (2014). https://doi.org/10.15438/rr.4.3.79
M. Saad, S. Akhtar, S. Srivastava, Mater. Today 5, 9 (2018). https://doi.org/10.1016/j.matpr.2018.06.393
M.T. Grapow, L.F. Melly, F.S. Eckstein, O.T. Reuthebuch, J. Cardiothorac. Surg. 7, 1–5 (2012). https://doi.org/10.1186/1749-8090-7-59
S.K. Ha, J.Y. Park, S.H. Kim, D.J. Lim, S.D. Kim, S.K. Lee, J. Korean Neurosurg. Soc. 44, 370–4 (2008). https://doi.org/10.3340/jkns.2008.44.6.370
P. Klimo Jr., M.W. Peelle, Spine J. 9, 959–66 (2009)
P.K. Sahoo, Apollo Med. 10, 233–236 (2013). https://doi.org/10.1016/j.apme.2013.08.009
M.K. Kasliwal, J.E. O’Toole, J. Clin. Neurosci. 21, 217–220 (2014). https://doi.org/10.1016/j.jocn.2013.03.018
R.F. Kersten, S.M. van Gaalen, A. de Gast, F.C. Oner, Spine J. 15, 1446–60 (2013)
C.C. Niu, J.C. Liao, W.J. Chen, L.H. Chen, J. Spinal, Disord. Tech. 23, 310–6 (2010)
Y. Chen, X. Wang, X. Lu, L. Yang, H. Yang, W. Yuan, Eur. Spine J. 22, 1539–1546 (2013). https://doi.org/10.1007/s00586-013-2772-y
C.M.B. Ho, S.H. Ng, Y.J. Yoon, Int. J. Precis. Eng. Manuf. 16, 1035–1046 (2015). https://doi.org/10.1007/s12541-015-0134-x
Acknowledgments
The authors would like to acknowledge the Ramalingaswami Re-Entry Fellowship, Department of Biotechnology (DBT), Government of India (BT/RLF/Re-entry/13/2016) and Science and Engineering Research Board (SERB), Department of Science & Technology, Government of India (PDF/2018/000182) for financial support. Authors would also like to acknowledge the Mission mode project titled "Medical Instruments & Devices" that has been sponsored by CSIR, Department of Science & Industrial Research, Ministry of S&T., Govt. of India (4/76/MlD/2020-lMD).
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Banerjee, K., Debroy, M., Balla, V.K. et al. Recent progress in 3D-printed polyaryletherketone (PAEK)-based high-performance polymeric implants for musculoskeletal reconstructions. Journal of Materials Research 36, 3877–3893 (2021). https://doi.org/10.1557/s43578-021-00231-4
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DOI: https://doi.org/10.1557/s43578-021-00231-4