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Nanomaterial-based ROS-mediated strategies for combating bacteria and biofilms

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Abstract

Nowadays, bacterial infection has become a severe threat to human health worldwide. The arising of antibiotic-resistant bacteria resulting from antibiotic abusing further adds the burden of bacterial infection treatment. It is the first priority to find more antibiotic-free solutions for combating bacteria, especially multi-drug-resistant bacteria. Compared to other antibiotic-free solutions, reactive oxidative species (ROS)-mediated strategies have outstanding advantages. Highly active ROS can directly cause oxidative damage and are less possible to bring about bacterial resistance. Photodynamic therapy (PDT), sonodynamic therapy (SDT), and enzyme-like catalytic therapy are three main methods to massively manufacture ROS. With the rapid development of nanotechnology, nanoparticles have been widely used in PDT and SDT. Nanoparticles with enzyme-like activities are also extensively studied. In this review, we introduced the application of nanomaterials in three ROS-mediated methods for combating bacteria and biofilms, which might provide important insights for antibiotic-free antibacterial strategies.

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Acknowledgments

This study was supported by the National Natural Science Foundation of China (Nos. 82071164, 81771122, 81970985, 81970984), Key research program of Sichuan Science and technology Department (Grant No. 2021YFS0052), and Open Project of Northwest Minzu University Key Laboratory of Oral Disease (Grant No. SZD201901).

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  1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, South Peoples Road, Chengdu, 610041, China

    Wenjia Xie, Shu Zhang, Fangwei Pan, Song Chen, Linna Zhong, Jian Wang & Xibo Pei

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  1. Wenjia Xie
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Xie, W., Zhang, S., Pan, F. et al. Nanomaterial-based ROS-mediated strategies for combating bacteria and biofilms. Journal of Materials Research 36, 822–845 (2021). https://doi.org/10.1557/s43578-021-00134-4

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