Abstract
Three-dimensional (3D) bioprinting uses the defined layer-by-layer deposition of living cells incorporated into biocompatible materials that can be used to create 3D models of human tissues. Functional 3D in vitro models can better mimic the complex architecture of human tissues in vivo providing more accurate cell-to-cell and cell-to-matrix interactions, and a better supply of nutrients, oxygen, and drugs to cells than standard two-dimensional cultures. This article examines recent advances and employments of these personalized models in cardiac, cancer, skin, and neuronal tissue applications based on the use of 3D printing and patient-derived cells, including induced pluripotent stem cells. These models can be used to generate patient-specific organ prototypes, drug screening platforms in preclinical studies, and engraftable tissues suitable for clinical practice proving themselves as promising new avenues for disease modeling, drug discovery, and regenerative medicine.
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The funding for this article was provided by the Canada Research Chairs Program (Tier II Chair in Biomedical Engineering), Natural Sciences and Engineering Research Council Discovery Grant Program, and the Canadian Institutes of Health Research - Institute of Neurosciences, Mental Health and Addiction Project Grant program.
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The idea for this article was S.M.W. The literature search was performed by J.P.W.-S. and S.S. J.P.W.-S. and S.S. drafted this work. S.M.W. and H.B.N. made critical revisions.
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S. Willerth is the CEO of Axolotl Biosciences, a startup focused on selling novel bioinks for bioprinting human tissue models. The remaining authors declare that there is no conflict of interest.
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Walters-Shumka, J.P., Sorrentino, S., Nygaard, H.B. et al. Recent advances in personalized 3D bioprinted tissue models. MRS Bulletin 48, 632–642 (2023). https://doi.org/10.1557/s43577-023-00551-2
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DOI: https://doi.org/10.1557/s43577-023-00551-2