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Integrating Colloidal Quantum Dots with Porous Silicon for High Sensitivity Biosensing

  • Materials And Sensors For Biomedical Applications
  • Published:
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Abstract

We aim to utilize the high surface area of a porous silicon (PSi) matrix coupled with semiconductor quantum dot (QD) amplifiers for ultrasensitive optical detection of small biomolecules using a dual-mode detection scheme. In our system, QDs attached to the target biomolecule serve as signal amplifiers by providing an additional refractive index increase beyond that of the smaller target molecules. The strong photoluminescence (PL) from the QDs serves as a secondary indication of target molecule attachment in the pores. A resulting increase in optical thickness of ∼190 nm and detection sensitivity of ∼700 nm/RIU have been demonstrated for attachment of glutathione capped CdTe QDs in the porous silicon matrix. Reflectance and PL measurements, combined with simulations, have been used to characterize the surface area coverage of the QDs within the porous framework, which is estimated at 10% for glutathione capped CdTe QDs.

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Authors and Affiliations

  1. Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, 37235, USA

    Girija Gaur & Sharon M. Weiss

  2. Department of Chemistry, Vanderbilt Institute of Nanoscale Science and Engineering, Vanderbilt University, Nashville, TN, 37235, USA

    Dmitry Koktysh

Authors
  1. Girija Gaur
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  2. Dmitry Koktysh
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  3. Sharon M. Weiss
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Gaur, G., Koktysh, D. & Weiss, S.M. Integrating Colloidal Quantum Dots with Porous Silicon for High Sensitivity Biosensing. MRS Online Proceedings Library 1301, 241–246 (2011). https://doi.org/10.1557/opl.2011.554

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  • DOI: https://doi.org/10.1557/opl.2011.554

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