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Development of forcespun fiber-aligned scaffolds from gelatin-zein composites for potential use in tissue engineering and drug release

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Abstract

In this study, based on the collection process, three-dimensional aligned fiber scaffolds from gelatin and zein protein were manufactured using Forcespinning®. The homogeneous blending of gelatin:zein (1:4) showed improved tensile and good hydrophobic properties (water contact angle of 115 °C). Cell viability, adhesion, proliferation, and drug release were measured. The cell viability was studied with human fibroblasts and a low cytotoxic effect was observed. Berberine drug release was measured and sustained release rate was observed over 15 days. The morphologic features, prolonged drug release, and cytotoxicity results suggest that these fibers could be appropriate for drug delivery and tissue engineering applications.

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Acknowledgment

The authors thank Consejo Nacional de Ciencia y Tecnologίa de Mexico (CONACyT; Project Number 242269) for financial support. The authors thank Dr. Karina Del Angel for water contact angle.

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Authors and Affiliations

  1. Tecnológico de Monterrey, Campus Monterrey, School of Engineering and Science, Eugenio Garza Sada 2501 Sur, Col Tecnológico, C.P. 64849, Monterrey, Nuevo León, México

    Narsimha Mamidi, Héctor Manuel Leija Gutiérrez, Enrique V. Barrera & Alex Elías-Zúñiga

  2. Tecnológico de Monterrey, Centro de Biotecnología-FEMSA, School of Engineering and Science, Av. Eugenio Garza Sada 2501, Monterrey, N.L., C.P. 64849, México

    Irasema Lopez Romo

  3. Department of Materials Science and NanoEngineering, Rice University, Houston, TX, 77005, USA

    Enrique V. Barrera

  4. Department of Chemistry, Rice University, Houston, TX, 77005, USA

    Enrique V. Barrera

Authors
  1. Narsimha Mamidi
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  2. Irasema Lopez Romo
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  3. Héctor Manuel Leija Gutiérrez
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  4. Enrique V. Barrera
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  5. Alex Elías-Zúñiga
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Correspondence to Narsimha Mamidi.

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Mamidi, N., Romo, I.L., Leija Gutiérrez, H.M. et al. Development of forcespun fiber-aligned scaffolds from gelatin-zein composites for potential use in tissue engineering and drug release. MRS Communications 8, 885–892 (2018). https://doi.org/10.1557/mrc.2018.89

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  • DOI: https://doi.org/10.1557/mrc.2018.89

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