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Fabrication of gelatin-poly(epichlorohydrin-co-ethylene oxide) fiber scaffolds by Forcespinning® for tissue engineering and drug release

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Abstract

Gelatin/poly(epichlorohydrin-co-ethylene oxide) [GL: PECO] composites are synthesized in a one-step process by the incorporation of elastic PECO and diclofenac. [GL: PECO] fibers are prepared by Forcespinning®. GL: PECO fibers are capable of diclofenac, by conjugation via a labile amide linkage. Fourier transform infrared spectroscopy (FTIR) results confirmed the chemical reactions and hydrogen bonds between gelatin, PECO, and diclofenac. Diclofenac drug release from GL: PECO fibers are measured for 15 days and prolonged drug release is observed. The cell viability is studied with NIH/3T3 and excellent results are observed. The sustained drug release and cytotoxicity results reveal that GL: PECO fibers could be promising substitutes for skin tissue engineering, wound healing, and drug delivery.

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Acknowledgments

The authors would like to acknowledge the financial support from the Consejo Nacional de Ciencia y Tecnología de México (CONACyT), Project Number 242269 and they thank Mónica Arreola Flores for her review of this paper. They also thank Dr. Alan Osiris Sustaita Narváez for the water contact angle.

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Authors and Affiliations

  1. Tecnológico de Monterrey, Campus Monterrey, School of Engineering and Science, Eugenio Garza Sada 2501 Sur, Col Tecnológico, C.P. 64849, Monterrey, Nuevo León, México

    Narsimha Mamidi, Héctor Manuel Leija Gutiérrez & Enrique V. Barrera

  2. Tecnológico de Monterrey, Centro de Biotecnología-FEMSA, School of Engineering and Science, Av. Eugenio Garza Sada 2501, Monterrey, N.L., C.P. 64849, México

    Javier Villela-Castrejón

  3. Department of Materials Science and NanoEngineering, Rice University, Houston, TX, 77005, USA

    Lucas Isenhart & Enrique V. Barrera

  4. Department of Chemistry, Rice University, Houston, TX, 77005, USA

    Enrique V. Barrera

  5. Tecnológico de Monterrey, Campus Monterrey, School of Engineering and Science, Eugenio Garza Sada 2501 Sur, Col Tecnológico, C.P. 64849, Monterrey, Nuevo León, México

    Alex Elías-Zúñiga

Authors
  1. Narsimha Mamidi
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  2. Héctor Manuel Leija Gutiérrez
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  3. Javier Villela-Castrejón
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  4. Lucas Isenhart
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  6. Alex Elías-Zúñiga
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Corresponding author

Correspondence to Narsimha Mamidi.

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The supplementary material for this article can be found at https://doi.org/10.1557/mrc.2017.117

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Mamidi, N., Gutiérrez, H.M.L., Villela-Castrejón, J. et al. Fabrication of gelatin-poly(epichlorohydrin-co-ethylene oxide) fiber scaffolds by Forcespinning® for tissue engineering and drug release. MRS Communications 7, 913–921 (2017). https://doi.org/10.1557/mrc.2017.117

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  • DOI: https://doi.org/10.1557/mrc.2017.117

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