Abstract
Development of universal biosensors based on electrical readout is currently limited by the difficulty of electrical signal transduction upon capture of neutral analytes. Kelley and co-workers demonstrate an elegant approach wherein an amplified electrical current flows to a multiplexed electrode array in proportion with the binding of nucleic acids, proteins, and small molecules—regardless of their inherent charge. Here we present a commentary on the strengths and limitations of this method.
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Soleymani, L. A new electronic assay enables ultrasensitive detection of diverse biological analytes—nucleic acids, proteins and small molecules—on a single integrated circuit. MRS Communications 2, 151–153 (2012). https://doi.org/10.1557/mrc.2012.24
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DOI: https://doi.org/10.1557/mrc.2012.24