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Blend-based fibers produced via centrifugal spinning and electrospinning processes: Physical and rheological properties

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Abstract

Cellprene™ is a recently developed polymeric blend based on poly(lactide-co-glycolide) (PLGA)/polyisoprene (PI) with good biological performance for biomedical applications. However, its potential as fiber scaffold in tissue engineering is still unknown, and the influence of processing parameters is yet to be understood. In this study, several compositions based on PLGA/PI blend mixed with hydroxyapatite (HAp) and polyethylene glycol (PEG) were prepared by solvent casting. Then, the membranes were used to produce micro/nanofibers by centrifugal spinning (CS) and electrospinning (ES). The viscosity’s effect was studied to find an ideal viscosity value to produce homogeneous micro/nanofibers. The in vitro bioactivity test was also performed. Rheological results showed that the best viscosity range was (0.105 Pa s > η > 0.138 Pa s) for CS; larger fibers of ES were produced with lower viscosities. The sample with the lowest HAp concentration exhibited thinner and more homogeneous non-beaded fibers and proved its bioactivity response.

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Acknowledgments

The authors gratefully acknowledge Coordination for the Improvement of Higher Education Personnel (CAPES–Brazil), National Council for Scientific and Technological Development (CNPQ–Brazil), Research Foundation of the State of Rio Grande do Sul (FAPERGS–Brazil), Funding Authority for Studies and Projects (FINEP–Brazil), and Erasmus for their financial support.

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Authors and Affiliations

  1. Laboratory of Biomaterials, Materials Engineering Department, Federal University of Rio Grande do Sul–UFRGS, Porto Alegre, RS90650-001, Brazil

    Nathália O. Muniz, Fernanda A. Vechietti, Guilherme R. Anesi & Luís Alberto L. dos Santos

  2. Center for Biomedical Technology, Universidad Politécnica de Madrid (UPM), Campus Montegancedo, Pozuelo de Alarcón, Madrid, 28223, Spain

    Nathália O. Muniz & Gustavo V. Guinea

  3. Mechanics and Composite Materials Department, Leibniz-Institut für Polymerforschung, Dresden, 01069, Germany

    Fernanda A. Vechietti

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  1. Nathália O. Muniz
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Correspondence to Nathália O. Muniz.

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Muniz, N.O., Vechietti, F.A., Anesi, G.R. et al. Blend-based fibers produced via centrifugal spinning and electrospinning processes: Physical and rheological properties. Journal of Materials Research 35, 2905–2916 (2020). https://doi.org/10.1557/jmr.2020.189

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