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High-resolution solid state NMR experiments for the characterization of calcium phosphate biomaterials and biominerals

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Abstract

Calcium phosphates form a vast family of biominerals, which have attracted much attention in fields like biology, medicine, and materials science, to name a few. Solid state Nuclear Magnetic Resonance (NMR) is one of the few techniques capable of providing information about their structure at the atomic level. Here, examples of recent advances of solid state NMR techniques are given to demonstrate their suitability to characterize in detail synthetic and biological calcium phosphates. Examples of high-resolution 31P, 1H (and 17O), solid state NMR experiments of a 17O-enriched monocalcium phosphate monohydrate-monetite mixture and of a mouse tooth are presented. In both cases, the advantage of performing fast Magic Angle Spinning NMR experiments at high magnetic fields is emphasized, notably because it allows very small volumes of sample to be analyzed.

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Acknowledgments

Financial support from the TGIR RMN THC FR3050 for conducting the research is gratefully acknowledged, as well as from CNRS (http://www.tgir-rmn.org/). The Royal Society is acknowledged for a Montpellier-Warwick partnership grant (JP090313), and Engineering and Physical Sciences Research Council (EPSRC) and the University of Warwick are thanked for partial funding of NMR work at Warwick. DL thanks the 7th European Community Framework Program, which supported this research by a Marie Curie European Reintegration Grant. Calculations were performed on the Institut du Developpement et des Ressources en Informatique Scientifique (IDRIS) supercomputer centre of the CNRS (Project 091461).

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  1. Laboratoire Chimie de la Matière Condensée de Paris, UMR CNRS 7574, UPMC Université Paris 06, Collège de France, 75231, Paris cedex 05, France

    Frédérique Pourpoint, Cristina Coelho Diogo, Christel Gervais & Christian Bonhomme

  2. CEMHTI, CNRS UPR 3079, 45071, Orléans cedex 2, France

    Franck Fayon

  3. INSERM Unité 563 (Centre de Physiopathologie de Toulouse Purpan), Université Paul-Sabatier, Hôpital Purpan, CHU de Toulouse, 31059, Toulouse cedex 9, France

    Sara Laurencin Dalicieux, Isabelle Gennero & Jean-Pierre Salles

  4. Department of Physics, University of Warwick, CV4 7AL, Coventry, UK

    Andrew P. Howes, Ray Dupree, John V. Hanna & Mark E. Smith

  5. Laboratoire de Minéralogie Cristallographie UMR CNRS 7590, UPMC Université Paris 06, France

    Francesco Mauri

  6. Institut Charles Gerhardt de Montpellier, UMR 5253, CNRS UM2 UM1 ENSCM, CC 1701 Université de Montpellier 2, 34095, Montpellier cedex 5, France

    Gilles Guerrero, P. Hubert Mutin & Danielle Laurencin

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  1. Frédérique Pourpoint
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Correspondence to Danielle Laurencin.

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Pourpoint, F., Diogo, C.C., Gervais, C. et al. High-resolution solid state NMR experiments for the characterization of calcium phosphate biomaterials and biominerals. Journal of Materials Research 26, 2355–2368 (2011). https://doi.org/10.1557/jmr.2011.250

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