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A solid-state NMR comparison of the mineral structure in bone from diseased joints in the horse

  • Nano- and micromechanical properties of hierarchical biological materials
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Abstract

In this work, subchondral cortical bone material is investigated from the joints of five horses, three of which presented with no clinical signs or radiographic signs of osteoarthritis and two of which suffered osteoarthritis joint disease, as judged by clinical and radiographic assessment and histological findings. The horse is a good model for osteoarthritis in humans, so the aim of this study is to use nuclear magnetic resonance (NMR) for a detailed investigation of the bone structure in bone material affected by osteoarthritis. In particular, we report on the assessment of the mineral structure of these samples as viewed by solid-state NMR.

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Authors and Affiliations

  1. Federal Institute for Materials Research and Testing, Division I.3, Working Group NMR Spectroscopy, Richard Willstaetter Str. 11, D-12489, Berlin, Germany

    Sergey Maltsev & Christian Jaeger

  2. Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK

    Melinda J. Duer

  3. Centre for Equine Studies, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk, CB8 7UU, UK

    Rachel C. Murray

Authors
  1. Sergey Maltsev
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  2. Melinda J. Duer
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  3. Rachel C. Murray
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  4. Christian Jaeger
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Corresponding author

Correspondence to Christian Jaeger.

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Maltsev, S., Duer, M.J., Murray, R.C. et al. A solid-state NMR comparison of the mineral structure in bone from diseased joints in the horse. J Mater Sci 42, 8804–8810 (2007). https://doi.org/10.1007/s10853-007-1916-z

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  • DOI: https://doi.org/10.1007/s10853-007-1916-z

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