Skip to main content
Log in

Magnesium-based Biodegradable Materials for Biomedical Applications

  • Published:
MRS Advances Aims and scope Submit manuscript

Abstract

Magnesium (Mg)-based biomaterials have attracted increasing attention in biomedical applications, such as orthopaedic, cardiovascular, urological, and neural applications because of the biocompatibility, biodegradability, antibacterial properties, and excellent mechanical properties. However, rapid degradation of Mg is the major concern for many clinical applications. Alloying Mg with other elements and engineering proper surfaces are the two approaches to control the degradation of Mg-based biomaterials. Our lab has investigated several classes of Mg-based biodegradable alloys and various surface treatment methods for medical implant and device applications. This mini-review highlights key research progress on Mg-based biomaterials and suggests future directions for Mg-based biomaterials.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. A. F. Cipriano, A. Sallee, R. G. Guan, Z. Y. Zhao, M. Tayoba, J. Sanchez and H. N. Liu, Acta Biomater 12, 298–321 (2015).

    Article  CAS  Google Scholar 

  2. Y. Zhang, J. Xu, Y. C. Ruan, M. K. Yu, M. O’Laughlin, H. Wise, D. Chen, L. Tian, D. Shi, J. Wang, S. Chen, J. Q. Feng, D. H. Chow, X. Xie, L. Zheng, L. Huang, S. Huang, K. Leung, N. Lu, L. Zhao, H. Li, D. Zhao, X. Guo, K. Chan, F. Witte, H. C. Chan, Y. Zheng and L. Qin, Nat Med 22 (10), 1160–1169 (2016).

    Article  CAS  Google Scholar 

  3. W. S. Jiang, Q. M. Tian, T. Vuong, M. Shashaty, C. Gopez, T. Sanders and H. N. Liu, Acs Biomater Sci Eng 3 (6), 936–950 (2017).

    Article  CAS  Google Scholar 

  4. J. Y. Lock, E. Wyatt, S. Upadhyayula, A. Whall, V. Nunez, V. I. Vullev and H. Liu, J Biomed Mater Res A 102 (3), 781–792 (2014).

    Article  Google Scholar 

  5. C. Zhang, N. Driver, Q. Tian, W. Jiang and H. Liu, J Biomed Mater Res A 0 (0) (2018).

  6. M. Sebaa, T. Y. Nguyen, S. Dhillon, S. Garcia and H. N. Liu, J Biomed Mater Res A 103 (1), 25–37 (2015).

    Article  Google Scholar 

  7. I. Johnson, K. Akari and H. N. Liu, Nanotechnology 24 (37) (2013).

  8. A. F. Cipriano, A. Sallee, R. G. Guan, A. Lin and H. N. Liu, Acs Biomater Sci Eng 3 (4), 540–550 (2017).

    Article  CAS  Google Scholar 

  9. R. G. Guan, A. F. Cipriano, Z. Y. Zhao, J. Lock, D. Tie, T. Zhao, T. Cui and H. N. Liu, Mater Sci Eng C Mater Biol Appl 33 (7), 3661–3669 (2013).

    Article  CAS  Google Scholar 

  10. I. Johnson and H. Liu, Plos One 8 (6) (2013).

  11. S. Bagherifard, D. J. Hickey, S. Fintová, F. Pastorek, I. Fernandez-Pariente, M. Bandini, T. J. ebster and M. Guagliano, Acta Biomater 66, 93–108 (2018).

    Article  CAS  Google Scholar 

  12. X. J. Wang, D. K. Xu, R. Z. Wu, X. B. Chen, Q. M. Peng, L. Jin, Y. C. Xin, Z. Q. Zhang, Y. Liu, X. H. Chen, G. Chen, K. K. Deng and H. Y. Wang, J Mater Sci Technol (2017).

    Google Scholar 

  13. J. Zhang, S. Hiromoto, T. Yamazaki, J. Niu, H. Huang, G. Jia, H. Li, W. Ding and G. Yuan, J Biomed Mater Res A 104 (10), 2476–2487 (2016).

    Article  CAS  Google Scholar 

  14. I. Johnson, S. M. Wang, C. Silken and H. Liu, Acta Biomater 36, 332–349 (2016).

    Article  CAS  Google Scholar 

  15. D. W. Zhao, F. Witte, F. Q. Lu, J. L. Wang, J. L. Li and L. Qin, Biomaterials 112, 287–302 (2017).

    Article  CAS  Google Scholar 

  16. A. Witecka, A. Yamamoto and W. Swieszkowski, Colloids Surf B Biointerfaces 150, 288–296 (2017).

    Article  CAS  Google Scholar 

  17. W. Jiang, A. F. Cipriano, Q. Tian, C. Zhang, M. Lopez, A. Sallee, A. Lin, M. C. C. Alcaraz, Y. Wu, Y. Zheng and H. Liu, Acta Biomater (2018).

    Google Scholar 

  18. Q. Tian and H. Liu, Nanotechnology 26 (17) (2015).

  19. A. F. Cipriano, J. J. Lin, C. Miller, A. Lin, M. C. C. Alcaraz, P. Soria and H. N. Liu, Acta Biomater 62, 397–417 (2017).

    Article  CAS  Google Scholar 

  20. I. Johnson, D. Perchy and H. Liu, J Biomed Mater Res A 100A (2), 477–485 (2012).

    Article  CAS  Google Scholar 

  21. I. Johnson, W. S. Jiang and H. N. Liu, Sci Rep 7 (2017).

  22. Q. M. Tian, M. Deo, L. Rivera-Castaneda and H. N. Liu, Acs Biomater Sci Eng 2 (9), 1559–1571 (2016).

    Article  CAS  Google Scholar 

  23. R. G. Guan, I. Johnson, T. Cui, T. Zhao, Z. Y. Zhao, X. Li and H. N. Liu, J Biomed Mater Res A 100a (4), 999–1015 (2012).

    Article  CAS  Google Scholar 

  24. A. F. Cipriano, T. Zhao, I. Johnson, R.-G. Guan, S. Garcia and H. Liu, J Mater Sci Mater Med 24 (4), 989–1003 (2013).

    Article  CAS  Google Scholar 

  25. T. Y. Nguyen, A. F. Cipriano, R.-G. Guan, Z.-Y. Zhao and H. Liu, J Biomed Mater Res A 103 (9), 2974–2986 (2015).

    Article  CAS  Google Scholar 

  26. A. F. Cipriano, J. J. Lin, A. Lin, A. Sallee, B. Le, M. C. C. Alcaraz, R. G. Guan, G. Botimer, S. Inceoglu and H. N. Liu, ACS Appl Mater Interfaces 9 (51), 44332–44355 (2017).

    Article  CAS  Google Scholar 

  27. A. F. Cipriano, A. Sallee, M. Tayoba, M. C. C. Alcaraz, A. Lin, R. G. Guan, Z. Y. Zhao and H. N. Liu, Acta Biomater 48, 499–520 (2017).

    Article  CAS  Google Scholar 

  28. D. Tie, R. G. Guan, H. N. Liu, A. Cipriano, Y. L. Liu, Q. Wang, Y. D. Huang and N. Hort, Acta Biomater 29, 455–467 (2016).

    Article  CAS  Google Scholar 

  29. Q. M. Tian, L. Rivera-Castaneda and H. N. Liu, Mater Lett 186, 12–16 (2017).

    Article  CAS  Google Scholar 

  30. H. Liu, J Biomed Mater Res A 99A (2), 249–260 (2011).

    Article  CAS  Google Scholar 

  31. N. Thanh Yen, C. G. Liew and H. Liu, Plos One 8 (10) (2013).

  32. M. A. Sebaa, S. Dhillon and H. Liu, J Mater Sci Mater Med 24 (2), 307–316 (2013).

    Article  CAS  Google Scholar 

  33. M. E. Iskandar, A. Aslani and H. Liu, J Biomed Mater Res A 101 (8), 2340–2354 (2013).

    Article  Google Scholar 

  34. M. E. Iskandar, A. Aslani, Q. Tian and H. Liu, J Mater Sci Mater Med 26 (5) (2015).

  35. H. Masuda, F. Hasegwa and S. Ono, J Electrochem Soc 144 (5), L127–L130 (1997).

    Article  CAS  Google Scholar 

  36. V. Zwilling, M. Aucouturier and E. Darque-Ceretti, Electrochim Acta 45 (6), 921–929 (1999).

    Article  CAS  Google Scholar 

  37. I. Sieber, H. Hildebrand, A. Friedrich and P. Schmuki, Electrochem commun 7 (1), 97–100 (2005).

    Article  CAS  Google Scholar 

  38. S. Minagar, C. C. Berndt, J. Wang, E. Ivanova and C. Wen, Acta Biomater 8 (8), 2875–2888 (2012).

    Article  CAS  Google Scholar 

  39. H. Liu and T. J. Webster, Biomaterials 28 (2), 354–369 (2007).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhang, C., Lin, J. & Liu, H. Magnesium-based Biodegradable Materials for Biomedical Applications. MRS Advances 3, 2359–2364 (2018). https://doi.org/10.1557/adv.2018.488

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1557/adv.2018.488

Navigation