Skip to main content
SpringerLink
Log in

Transmission electron microscopic studies on an initial stage in the conversion process from α-tricalcium phosphate to hydroxyapatite

  • Articles
  • Published:
Journal of Materials Research Aims and scope Submit manuscript

Abstract

The microstructural changes in the initial stage of a conversion process of α-tricalcium phosphate [α-Ca3(PO4)2] (α-TCP) to hydroxyapatite [Ca10(PO4)6(OH)2] (HAp) by the hydrolysis method were investigated by transmission electron microscopy (TEM). To investigate the microstructural changes that take place during the conversion process, we prepared two types of α-TCP specimens for TEM: α-TCP powder and sintered α-TCP thin film. According to our results, the microstructural changes can be summarized as follows. At first, the surface of the α-TCP was covered with an amorphous calcium phosphate layer, resulting from hydration or the dissolution of α-TCP. Subsequently, the nucleation of HAp occurred on the amorphous layer, and then dendritic structures appeared on the layer. Thereafter, the dendritic structures would grow into needlelike fine HAp crystals.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. W.L. Suchanek and M. Yoshimura, J. Am. Ceram Soc. 81, 765 (1998).

    Article  CAS  Google Scholar 

  2. M. Tamai, S. Miki, G. Pezzotti, and A. Nakahira, J. Ceram. Soc. Jpn. 108, 915 (2000).

    Article  CAS  Google Scholar 

  3. W.L. Suchanek, M. Yashima, M. Kakihana, and M. Yoshimura, J. Am. Ceram. Soc. 80, 2805 (1997).

    Article  CAS  Google Scholar 

  4. N. Matsuda, F. Kaji, and M. Watanabe, Phosph. Res. Bull. 6, 345 (1996).

    Article  CAS  Google Scholar 

  5. M.A. Verges, C.F. Gonzalez, and M.M. Gallego. J. Eur. Ceram. Soc. 18, 1245 (1998).

    Article  Google Scholar 

  6. H.S. Lie, T.S. Chin, L.S. Lai, S.Y. Chiu, K.H. Chung, C.S. Chang, and M.T. Lui. Ceram. Int. 23, 19 (1997).

    Article  Google Scholar 

  7. T. Kanazawa, Inorganic Phosphate Chemistry, Kodansha Scientific (1985).

  8. H. Monma and K. Kanazawa, J.Ceram. Soc. Jpn. 86, 73 (1978).

    CAS  Google Scholar 

  9. H. Monma, S. Ueno, and K. Kanazawa, J. Chem. Tech. Biotechnol. 31, 15 (1981).

    Article  CAS  Google Scholar 

  10. H. Monma and T. Kanazawa, J. Ceram. Soc. Japan. 84, 209 (1976).

    CAS  Google Scholar 

  11. K. Sakamoto, A. Nakahira, M. Okazaki, J. Ichihara, M. Inoue, and S. Yamaguch, in Organic/Inorganic Hybrid Materials, edited by R.M. Laine, C. Sanchez, C.J. Brinker, and E. Giannelis (Mater. Res. Soc. Symp. Proc. 519, Warrendale, PA, 1998), pp. 407–411.

  12. A. Nakahira, K. Sakamoto, S. Yamaguchi, M. Kaneno, S. Takeda, and M. Okazaki, J. Am. Ceram. Soc. 82, 2029 (1999).

    Article  CAS  Google Scholar 

  13. A. Nakahira, M. Tami, K. Sakamoto, and S. Yamaguch, J. Ceram. Soc. Jpn. 108, 99 (2000).

    Article  CAS  Google Scholar 

  14. E.D. Eanes, I.H. Gillessen, and A.S. Posner, Nature 23, 365 (1965).

    Article  Google Scholar 

  15. E.D. Eanes, J.D. Termine, and M.U. Nylen, Calicif. Tiss. Res. 12, 143 (1973).

    Article  CAS  Google Scholar 

  16. J. Christoffersen, M.R. Christoffersen, W. Kibalczyc, and F.A. Andersen, J. Crystal Growth 94, 767 (1989).

    Article  CAS  Google Scholar 

  17. A.L. Boskey and A.S.Posner, J. Phys. Chem. 77, 2313 (1973).

    Article  CAS  Google Scholar 

  18. E.D. Eanes and A.S. Posner. Trans. N.Y. Acad. Sci. 28, 233 (1965).

    Article  CAS  Google Scholar 

  19. R.R. Clement, A.L. Macipe, J.G. Morales, J.T. Burgues, and V.M. Castano, J. Eur. Ceram. Soc. 18, 1351 (1998).

    Article  Google Scholar 

  20. K. Onuma and A. Ito, Chem. Mater. 10, 3346 (1998).

    Article  CAS  Google Scholar 

  21. N. Kanzaki, G. Treboux, K. Onuma, S. Tsutsumi, and A. Ito. Biomaterials 22, 2921 (2001).

    Article  CAS  Google Scholar 

  22. G. Treboux, P. Layrolle, N. Kanzaki, K. Onuma, and A. Ito, J. Am. Chem. Soc. 122, 8323 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Graduate School of Science and Technology, Kyoto Institute of Technology, Gosho-kaido-cho, Matsugasaki, Sakyo-ku, Kyoto, 606-8585, Japan

    Masato Tamai & Mitsuhiro Nakamura

  2. Department of Electronics and Information Science, Kyoto Institute of Technology, Gosho-kaido-cho, Matsugasaki, Sakyo-ku, Kyoto, 606-8585, Japan

    Toshiyuki Isshiki, Koji Nishio, Atsushi Nakahira & Hisamitsu Endoh

Authors
  1. Masato Tamai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Toshiyuki Isshiki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Koji Nishio
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mitsuhiro Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Atsushi Nakahira
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hisamitsu Endoh
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tamai, M., Isshiki, T., Nishio, K. et al. Transmission electron microscopic studies on an initial stage in the conversion process from α-tricalcium phosphate to hydroxyapatite. Journal of Materials Research 18, 2633–2638 (2003). https://doi.org/10.1557/JMR.2003.0368

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1557/JMR.2003.0368

Search

Navigation