Summary
The reversed-phase thin layer chromatographic retention behavior of some new derivatives of 1,2,4-triazole and thiosemicarbazide has been determined. Linear relationships were established between the retention (RM) of each solute and the volume fraction of organic modifier (methanol or acetonitrile) in organic-aqueous mobile phases. This enabled determination of chromatographic lipophilic-ity data - RMW values by extrapolation, φ0 by interpolation for each organic modifier, and S denoting the slope of the linear dependences. Moderate correlation was established between chromato-graphic lipophilicity and log PG calculated by use of Chem Plus software. Experimental lipophilicity log PTLC was also determined for each solute by the use of a special calibration plot prepared by use of selected sulfonamide standards for the two mobile phase systems used in this study. The effect of different mobile-phase modifiers on experimentally obtained lipophilicity was studied and compared.
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Flieger, J., Tatarczak, M., Wujec, M. et al. RP-TLC Determination of the Lipophilicity of Some New Derivatives of 1,2,4-Triazole and Thiosemicarbazide with Potential Antituberculosis Activity. JPC-J Planar Chromat 19, 32–41 (2006). https://doi.org/10.1556/JPC.19.2006.1.6
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DOI: https://doi.org/10.1556/JPC.19.2006.1.6