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Serum interleukin-6 soluble receptor in relation to interleukin-6 in stroke patients

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Abstract

Cerebral ischemia triggers interleukin-6 (IL-6) release into blood. IL-6 is a key mediator of acute phase reaction. Markers of acute phase reaction (C-reactive protein, fibrinogen, fever) have been linked to poor prognosis in stroke patients. Interleukin-6 soluble receptor (sIL-6R) can potentiate IL-6 pro-inflammatory activity. The aim of this study was to investigate the relationship between IL-6 and sIL-6R in stroke patients. Serum cytokine levels were measured in 18 stroke patients and 13 controls using the ELISA method. On the second day of stroke, IL-6 levels were significantly higher in stroke patients than in controls; sIL-6R levels did not differ significantly between groups. Three months after stroke, IL-6 levels did not differ significantly between groups; sIL-6R levels were significantly decreased in stroke patients when compared with that in controls and with levels in acute phase of stroke. Decreased sIL-6R early after stroke might reflect a regulatory mechanism attenuating inflammatory response.

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Authors and Affiliations

  1. Department of Neurology, Collegium Medicum, Jagiellonian University, Krakow, Poland

    Tomasz Dziedzic, Elzbieta A. Gryz, Wojciech Turaj, Agnieszka Slowik & Andrzej Szczudlik

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  1. Tomasz Dziedzic
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  2. Elzbieta A. Gryz
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  3. Wojciech Turaj
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  4. Agnieszka Slowik
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  5. Andrzej Szczudlik
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Correspondence to Tomasz Dziedzic.

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Dziedzic, T., Gryz, E.A., Turaj, W. et al. Serum interleukin-6 soluble receptor in relation to interleukin-6 in stroke patients. J Mol Neurosci 24, 293–298 (2004). https://doi.org/10.1385/JMN:24:2:293

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  • DOI: https://doi.org/10.1385/JMN:24:2:293

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