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Discoidin domain receptor 1

A new class of receptor regulating leukocyte-collagen interaction

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Abstract

Previous studies demonstrated that type I collagen, a major component of the extracellular matrix, could influence the differentiation and function of leukocytes; however, it is not clear whether those effects of collagen were based on its interaction with the classic collagen receptors. α1β1 and α2β1 integrins. We recently detected significant upregulation of discoidin domain receptor 1 (DDR 1), a new class of collagen receptor, in human leukocytes, including neutrophils, monocytes, and lymphocytes, in vitro, leading to the hypothesis that the leukocyte-activating effects of collagen might be owing to its interaction with DDR1. In this review, we summarize our recent findings demonstrating that DDR1-collagen interaction facilitates the adhesion, migration, differentiation/maturation, and cytokine/chemokine production of leukocytes. We also describe the intracellular signaling pathways activated by DDR1 interaction with collagen.

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  1. Teizo Yoshimura

    Present address: Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Building 599, Room 9, 21702, Frederick, MD

Authors and Affiliations

  1. Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Building 599, Room 9, 21702, Frederick, MD

    Wataru Matsuyama & Hidenobu Kamohara

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  1. Teizo Yoshimura
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  2. Wataru Matsuyama
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  3. Hidenobu Kamohara
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Yoshimura, T., Matsuyama, W. & Kamohara, H. Discoidin domain receptor 1. Immunol Res 31, 219–229 (2005). https://doi.org/10.1385/IR:31:3:219

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