Abstract
The enzyme-to-enzyme channeling of metabolic intermediates is not an uncommon process. The present review draws attention to recent experimental work documenting, in rat pancreatic islets, the enzyme-to-enzyme channeling of α-d-glucose 6-phosphate between hexokinase isoenzyme(s), mainly glucokinase, and phosphoglucoisomerase. Likewise, the possible enzyme-to-enzyme channeling of β-d-fructose 6-phosphate between phosphoglucoisomerase and phosphofructokinase is briefly evoked. These considerations are relevant to the anomeric specificity of d-glucose metabolism, even in islets exposed to equilibrated d-glucose, to the perturbation of such an anomeric specificity in the phenomenon of so-called B-cell glucotoxicity, and to the correct interpretation of 3HOH generation from d-[2-3H]glucose.
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Malaisse, W.J., Zhang, Y. & Sener, A. Enzyme-to-enzyme channeling in the early steps of glycolysis in rat pancreatic islets. Endocr 24, 105–109 (2004). https://doi.org/10.1385/ENDO:24:2:105
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DOI: https://doi.org/10.1385/ENDO:24:2:105