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The renal type IIa Na/Pi cotransporter

Structure-function relationships

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Abstract

The type IIa Na/Pi cotransporter mediates proximal tubular brush-border membrane secondary active phosphate (Pi) flux. It is rate limiting in tubular Pi reabsorption and, thus, a final target in many physiological and pathophysiological situations of altered renal Pi handling (1–4). In the present short review, we will briefly summarize our current knowledge about the transport mechanism (cycle) as well as particular regions of the transporter protein (“molecular domains”) that potentially determine transport characteristics.

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Authors and Affiliations

  1. Physiologisches Institut, Universität Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland

    Heini Murer, Katja Köhler, Georg Lambert, Gerti Stange, Jürg Biber & Ian Forster

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  1. Heini Murer
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  2. Katja Köhler
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  3. Georg Lambert
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  4. Gerti Stange
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  5. Jürg Biber
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  6. Ian Forster
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Correspondence to Heini Murer.

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Murer, H., Köhler, K., Lambert, G. et al. The renal type IIa Na/Pi cotransporter. Cell Biochem Biophys 36, 215–220 (2002). https://doi.org/10.1385/CBB:36:2-3:215

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