Abstract
The thiazide-sensitive NaCl cotransporter (NCC, SLC12A3) is a member of the solute carrier 12 (SLC12) family of electroneutral cotransporters. NCC is expressed in the distal convoluted tubule (DCT) of the kidney, where it mediates the transport of sodium with chloride in 1:1 stoichiometry. NCC is responsible for reabsorbing approximately 5–10% of sodium from the glomerular filtrate. NCC plays a key role in determining the blood pressure set point and potassium balance. NCC is the major molecular target of thiazide-type diuretics, drugs commonly used as first-line agents in the treatment of essential hypertension and edema. Since its cloning decades ago, much has been learned about the physiological transport properties of NCC, its regulation, and its connections to human disease. In this chapter, I provide an overview of the biology of this important cotransporter.
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This work was supported by grants from the NIH (R01-DK098145 and R01-DK119252), and by the VA Pittsburgh Healthcare System Research Service.
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Subramanya, A.R. (2020). Thiazide-Sensitive NaCl Cotransporter. In: Hamilton, K.L., Devor, D.C. (eds) Studies of Epithelial Transporters and Ion Channels. Physiology in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-55454-5_3
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