Abstract
A new vanadyl(IV) complex of the disaccharide lactose was obtained in aqueous solution at pH=13. The sodium salt of the complex, of composition Na4[VO(lactose)2]·3H2O, has been characterized by elemental analysis and by ultraviolet-visible, diffuse reflectance, and infrared spectroscopies. Its magnetic susceptibility and thermal behavior were also investigated. The inhibitory effect on alkaline phosphatase activity was tested for this compound as well as for the vanadyl(IV) complexes with maltose, sucrose, glucose, fructose, and galactose. For comparative purposes, the free ligands and the vanadyl(IV) cation were also studied. The free sugars and the sucrose/VO complex exhibited the lowest inhibitory effect. Lactose-VO, maltose-VO, and the free VO2+ cation showed an intermediate inhibition potential, whereas the monosaccharide/VO complexes appeared as the most potent inhibitory agents.
Similar content being viewed by others
References
H. Sigel and A. Sigel, eds., Metal Ions in Biological Systems, Vol. 31. Vanadium and its Role in Life, Marcel Dekker, New York (1995).
E. J. Baran, Los “nuevos” bioelementos. Realidad y especulaciones, Anal. Soc. Cientif. Argent. 228, 61–74 (1998).
C. Slebodnick, B. J. Hamstra, and V. L. Pecoraro, Modeling the biological chemistry of vanadium: structural and reactivity studies elucidating biological function, Struct. Bonding 89, 51–107 (1997).
E. J. Baran, Oxovanadium (IV) and oxovanadium (V) complexes relevant to biological systems, J. Inorg. Biochem. 80, 1–10 (2000).
E. J. Baran, Model studies related to vanadium metabolism, Bol. Soc. Chil. Quim. 42, 247–256 (1997).
E. J. Baran, Vanadium detoxification, In Vanadium in the Environment, J. O. Nriagu, ed. Wiley, New York, Part 2, pp. 317–345 (1998).
R. P. Bandwar and C. P. Rao, Relative reducing activities in vitro of some hydroxycontaining compounds, including monosaccharides, towards vanadium (V) and molybdenum (VI), Carbohydr. Res. 277, 197–207 (1995).
A. Sreedhara, N. Susa, A. Patwardhan, and C. P. Rao, One electron reduction of vanadate (V) to oxovanadium (IV) by low-molecular-weight biocomponents like saccharides and ascorbic acid: effects of oxovanadium (IV), Biochem. Biophys. Res. Commun. 224, 115–120 (1996).
A. Sreedhara, N. Susa, and C. P. Rao, Vanadate and chromate reduction by saccharides and l-ascorbic acid: effect of isolated V (IV) and Cr (III) products on DNA nicking, lipid peroxidation, cytotoxicity and on enzymatic and non-enzymatic antioxidants Inorg. Chim. Acta 263, 189–194 (1997).
E. J. Baran, Carbohydr. Chem, in press.
A. M. Cortizo and S. B. Etcheverry, Vanadium derivatives act as growth factor-mimetic compounds upon differentiation and proliferation of osteoblast-like UMR106 cells, Mol. Cell Biochem. 145, 97–102 (1995).
E. J. Baran, La nueva farmacoterapia inorgánica. XVII. Compuestos de vanadio, Acta Farm. Bonaerense 16, 43–52 (1997).
K. H. Thompson, J. H. McNeill, and C. Orvig, Vanadium compounds as insulin mimics, Chem. Rev. 99, 2561–2571 (1999).
K. H. Thompson and C. Orvig, Design of vanadium compounds as insulin enhancing agents, J. Chem. Soc. Dalton Trans. 2885–2892 (2000).
S. B. Etcheverry, P. A. M. Williams, and E. J. Baran, Synthesis and characterization of oxovanadium(IV) complexes with saccharides, Carbohydr. Res., 302, 131–138 (1997).
P. A. M. Williams, S. B. Etcheverry, and E. J. Baran, Characterization of new oxovanadium (IV) complexes of saccharides, Carbohydr. Res. 329, 41–47 (2000).
H. Onishi, Photometric Determination of Traces of Metals, 4th edit. Wiley, New York, Part IIB, pp. 674–676 (1989).
H. G. Seiler, A. Sigel, and H. Sigel, eds., Handbook on Metals in Clinical and Analytical Chemistry, Marcel Dekker, New York, p. 573 (1994).
J. Selbin, The chemistry of oxovanadium (IV), Chem. Rev. 65, 153–175 (1965).
A. Syamal, Spin-spin coupling in oxovanadium (IV) complexes, Coord. Chem. Rev. 16, 309–339 (1975).
E. J. Baran, J. Coord. Chem., in press.
P. D. Vasko, J. Blackwell, and J. L. Koenig, Infrared and Raman spectroscopy of carbohydrates. Part I: identification of O-H and C-H-related vibrational modes for d-glucose, maltose, cellobiose, and dextran by deuterium substitution methods, Carbohydr. Res. 19, 297–310 (1971).
J. J. Cael, J. L. Koenig, and J. Blackwell, Infrared and Raman spectroscopy of carbohydrates. Part IV: identification of configuration- and configuration-sensitive modes for d-glucose by normal coordinate analysis, Carbohydr. Res. 32, 79–91 (1974).
H. Susi and J. S. Ard, Laser-Raman spectra of lactose, Carbohydr. Res. 37, 351–354 (1974).
V. M. Tul’chinsky, S. E. Zurabyan, K. A. Asankozhoev, G. A. Kogan, and A. Ya. Khorlin, Study of the infrared spectra of oligosaccharides in the region 1000-40 cm−1, Carbohydr. Res. 51, 1–8 (1976).
M. Mathlouthi and J. L. Koenig, Vibrational spectra of carbohydrates Adv. Carbohydr. Chem. Biochem. 44, 7–89 (1986).
F. S. Parker, Applications of Infrared, Raman and Resonance Raman Spectroscopy in Biochemistry, Plenum, New York (1983).
I. Bertini and C. Luchinat, An insight on the active site of zinc enzymes through metal substitution, in Metal Ions in Biological Systems, H. Sigel, ed., M. Dekker, New York Vol. 15, pp. 101–156 (1983).
D. M. Whitfield, S. Stojkovski, and B. Sarkar, Metal coordination to carbohydrates. Structure and function, Coord. Chem. Rev. 122, 171–225 (1993).
R. P., Bandwar, M. S. S. Raghavan, and C. P. Rao, Transition-metal saccharide chemistry: d-glucose complexes of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II), Biometals 8, 19–24 (1995).
K. Kustin, Perspectives in vanadium biochemistry, in Vanadium Compounds: Chemistry, Biochemistry and Therapeutic Applications, A. S. Tracey and D. C. Crans, eds., ACS Symposium Series 711, American Chemical Society, Washington, DC, pp. 170–185 (1998).
C. V. Grant, K. M. Geiser-Busch, C. R. Cornman, and R. D. Britt, Probing the molecular geometry of five-coordinate vanadyl complexes with pulsed ENDOR, Inorg. Chem. 38, 6285–6288 (1999).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Etcheverry, S.B., Barrio, D.A., Williams, P.A.M. et al. On the interaction of the vanadyl(IV) cation with lactose. Biol Trace Elem Res 84, 227–238 (2001). https://doi.org/10.1385/BTER:84:1-3:227
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1385/BTER:84:1-3:227