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Mucosal uptake and whole-body retention of dietary manganese are not altered in β2-microglobulin knockout mice

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Abstract

To further examine the interrelationships between manganese and iron absorption, the mucosal uptake, initial rate of loss, wholebody retention, and tissue distribution of an orally administered 54Mn radiotracer were compared between normal and β2-microglobulin knockout [β2m(-/-)] mice. These mutant mice are commonly used as a model for the study of human hemochromatosis, a hereditary ironoverload disease. Initial uptake of 54Mn by the intestinal mucosa, the liver, and the brain was not different between the two strains. The mutant mice had much higher concentrations of nonheme and total iron in the liver, but hepatic manganese, copper, magnesium, and zinc concentrations were similar between the two strains. In summary, the mucosal uptake and whole-body retention of manganese and tissue manganese concentrations were not altered in β2m(-/-) mice; this suggests that normal homeostasis of manganese is not affected by the altered HFE protein-β2m complex in these mice.

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Authors and Affiliations

  1. US Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, 58202-9034, Grand Forks, ND

    Z. K. (Fariba) Roughead & John W. Finley

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  1. Z. K. (Fariba) Roughead
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  2. John W. Finley
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Mention of a trademark or proprietary product does not constitute a guarantee or warranty of the product by the US Department of Agriculture and does not imply its approval to the exclusion of other products that may also be suitable. The US Department of Agriculture, Agricultural Research Service, Northern Plains Area, is an equal opportunity/affirmative action employer and all agency services are available without discrimination.

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(Fariba) Roughead, Z.K., Finley, J.W. Mucosal uptake and whole-body retention of dietary manganese are not altered in β2-microglobulin knockout mice. Biol Trace Elem Res 80, 231–244 (2001). https://doi.org/10.1385/BTER:80:3:231

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  • DOI: https://doi.org/10.1385/BTER:80:3:231

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