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Age-related attenuation in the elements in monkey sino-atrial node

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Abstract

Changes in trace elements of the sino-atrial (SA) node with aging was investigated using 24 hearts of the Japanese and rhesus monkeys of ages ranging from 27 d to 30 yr. With aging, sympathetic activity decreases and SA nodal function deterionates. The SA nodal tissue was removed from the anatomical position and was confirmed by means of histological observation. The elements, such as Ca, P, S, Mg, Na, Fe, and Zn, were analyzed using inductively coupled plasma-atomic emission spectrometry (ICP-AES). Advancing age never increased the contents of the trace elements, but decreased them. The correlation coefficients for the age-dependent attenuations were −0.561 (n=24, p<0.01) in Ca and −0.482 (n=24, p<0.05) in P. The correlations for the attenuations induced by other trace elements were not significant. Furthermore, close relationships of the elements between Ca and P, S, Zn, or Na contents, between P and Zn or Na contents, and between Zn and Na contents were observed. These results indicate that the elements in the monkey SA node are attenuated with an increase in age, presumably suggesting the age-related suppression of cardiac functions as a result of the histological alterations of the SA nodal cells.

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Authors and Affiliations

  1. Department of Pharmacology, Division of Molecular and Cellular Biology, Nara Medical University, School of Medicine, Kashihara, 634-8521, Nara, Japan

    Hiroyasu Satoh

  2. Laboratory of Cell Biology, Department of Anatomy, Nara Medical University, School of Medicine, Kashihara, 634-8521, Nara, Japan

    Setsuko Tohno, Cho Azuma & Yoshiyuki Tohno

  3. Laboratory of Environmental Biology, Department of Life Science, Faculty of Science and engineering, Kinki University, Higashi-Osaka, 577-8502, Osaka, Japan

    Takeshi Minami

  4. Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, Inuyama, 484-8506, Aichi, Japan

    Takao Ohishi & Motoharu Hayashi

Authors
  1. Hiroyasu Satoh
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  2. Setsuko Tohno
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  3. Cho Azuma
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  4. Takeshi Minami
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  5. Takao Ohishi
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  6. Motoharu Hayashi
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  7. Yoshiyuki Tohno
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Satoh, H., Tohno, S., Azuma, C. et al. Age-related attenuation in the elements in monkey sino-atrial node. Biol Trace Elem Res 107, 43–51 (2005). https://doi.org/10.1385/BTER:107:1:043

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  • DOI: https://doi.org/10.1385/BTER:107:1:043

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