Abstract
Increased intake of chromium (Cr) often leads to improvements in glucose, insulin, lipids, and related variables in studies involving humans and experimental and farm animals. However, the results are often variable, depending not only on the selection of subjects but also dietary conditions and the form of supplemental Cr used. Our objective was to find a Cr supplement suitable for humans that was absorbed better than any of those available. Chromium absorption by six adult subjects, three males and three females, was determined based on the amount of Cr excreted in the urine in the initial 2 d following intake of 200 μg of Cr of the various forms of chromium tested. The absorption of the newly synthesized complexes was greatest for those containing histidine. Urinary Cr losses for six control subjects consuming 200 μg of Cr as Cr histidinate increased from basal levels of 256±48 to 3670±338 ng/d compared with 2082±201 ng for Cr picolinate, the currently most popular nutrient supplement, in the 48h following Cr consumption. Chromium histidinate complexes were stable and absorption was similar to the initial values after more than 2 yr. Mixing of some of the complexes with starch, which was postulated to improve Cr absorption, was shown to essentially block Cr absorption within 1 mo. These data demonstrate that urinary Cr losses need to be determined because stability and absorption of the Cr complexes varies widely and could be responsible for the variability in some of the Cr supplementation studies. Chromium ***DIRECT SUPPORT *** A02Q2015 00003 histidinate complexes are absorbed better than any of the Cr complexes currently available and need to be evaluated as Cr nutritional supplements.
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R. A. Anderson, Chromium, glucose intolerance and diabetes, J. Am. Coll. Nutr. 17, 548–555 (1998).
R. A. Anderson, Insulin, glucose intolerance and diabetes: recent data regarding the chromium connection, Trace Elements Nutr. Health Dis. Proc. First Int. Bio-miner. Symp. 1, 79–86 (2002).
R. A. Anderson, Chromium in the prevention and control of diabetes, Diabetes Metab. 26, 22–27 (2000).
R. A. Anderson, Chromium and insulin sensitivity. Nutr. Res. Rev. 16, 267–275 (2003).
S. A. Katz and H. Salem. The Biological and Environmental Chemistry of Chromium, VCH Publishers Inc., NY, NY (1994), p. 19.
K. L. Olin, D. M. Stearns, W. H. Armstrong, and C. L. Keen, Comparative retention/absorption of 51 chromium (51Cr) from 51 chloride, 51 nicotinate and 51 picolinate in a rat model, Trace Elements Electrolytes, 11, 182–186 (1994).
R. A. Anderson, N. A. Bryden, M. M. Polansky, and K. Gautschi, Dietary chromium effects on tissue chromium concentrations and chromium absorption in rats, J. Trace Elements Exp. Med. 9, 11–25 (1996).
C. D. Seaborn and B. J. Stoecker, Effects of starch, sucrose, fructose and glucose on chromium absorption and tissue concentrations in obese and lean mice, J. Nutr. 119, 1444–1451 (1989).
R. A. Anderson, M. M. Polansky, N. A. Bryden, et al. Urinary chromium excretion of human subjects: effects of chromium supplementation and glucose loading, Am. J. Clin. Nutr. 36, 1184–1193 (1982).
C. Veillon, W. R. Wolf, and B. E. Guthrie, Determination of chromium in biological materials by stable isotope dilution, Anal. Chem. 51, 1022–1024, (1979).
R. A. Anderson, M. M. Polansky, N. A. Bryden, K. Y. Patterson, C. Veillon, and W. H. Glinsmann, Effects of chromium supplementation on urinary Cr excretion of human subjects and correlation of Cr excretion with selected clinical parameters, J. Nutr. 113, 276–281 (1983).
R. A. Anderson, A. M. Roussel, N. Zouari, S. Mahjoub, J. M. Matheau, and A. Kerkeni, Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus, J. Am. Coll. Nutr. 20, 212–218 (2001).
E. B. Kegley, D. L. Galloway, and T. M. Fakler, Effect of dietary chromium—l-methionine on glucose metabolism of beef steers, J. Anim. Sci. 78, 3177–3183 (2000).
R. J. Doisy, D. H. P. Streeten, D. H. P. Souma, M. E. Kalafer, S. L. Rekant, and T. G. Dalakos, Metabolism of chromium 51 in human subjects, in Newer Trace Elements in Nutrition, W. Mertz and W. E. Cornatzer, eds., Marcel Dekker, New York (1971).
M. A. Rubin, J. P. Miller, A. S. Ryan, et al., Acute and chronic resistive exercise increase urinary chromium excretion in men as measured with an enriched chromium stable isotope, J. Nutr. 128, 73–78 (1998).
M. L. Gargas, R. L. Norton, D. J. Paustenbach and B. L. Finley, Urinary excretion of chromium by humans following ingestion of chromium picolinate. Implications for biomonitoring [see comments], Drug Metab. Dispos. 22, 522–529 (1994).
W. W. Campbell, L. J. Joseph, S. L. Davey, D. Cyr-Campbell, R. A. Anderson, and W. J. Evans, Effects of resistance training and chromium picolinate on body composition and skeletal muscle in older men, J. Appl. Physiol. 86, 29–39 (1999).
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Anderson, R.A., Polansky, M.M. & Bryden, N.A. Stability and absorption of chromium and absorption of chromium histidinate complexes by humans. Biol Trace Elem Res 101, 211–218 (2004). https://doi.org/10.1385/BTER:101:3:211
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DOI: https://doi.org/10.1385/BTER:101:3:211