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An Integrated Approach Based on Experimental Designs for Fingerprint Development of the Complex Herbal Prescription Sheng-Mai-San by MEKC

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Abstract

An integrated strategy based on experimental designs for the development, optimization and validation of the fingerprint method of Sheng-Mai-San by MEKC has been described. Orthogonal and sequential uniform designs were employed to select important experimental parameters and optimize CE conditions. Method validation was performed in terms of injection precision, sample stability test and robustness testing. Additionally, conventional modeling method was used to predict the optimum separation conditions for comparative purpose. The strategy described can also be utilized for fingerprint development in the quality control of other herbal medicines.

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Acknowledgments

This research work was financially supported by the National Natural Science Foundation of China (Grant No 30772792).

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Authors and Affiliations

  1. Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, Nanjing, 210009, China

    Xiao-Mei Fan & Yi-Bing Ji

  2. Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, 210009, China

    Xiao-Mei Fan & Yi-Bing Ji

  3. Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing, 210009, China

    Da-Ni Zhu

Authors
  1. Xiao-Mei Fan
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  2. Yi-Bing Ji
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  3. Da-Ni Zhu
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Correspondence to Yi-Bing Ji.

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Fan, XM., Ji, YB. & Zhu, DN. An Integrated Approach Based on Experimental Designs for Fingerprint Development of the Complex Herbal Prescription Sheng-Mai-San by MEKC. Chroma 71, 667–677 (2010). https://doi.org/10.1365/s10337-010-1519-8

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