Abstract
A new, rapid, and efficient method, multiple reaction monitoring liquid chromatography–tandem mass spectrometry, has been developed for analysis of nanafrocin in foodstuffs of animal origin. The researchers used a C18 stationary phase coupled with triple-quadrupole tandem mass spectrometry in negative-electrospray mode. The limits of detection (LOD) and quantification (LOQ) were 0.005 and 0.01 mg kg−1, respectively, in the matrixes. Detector response was found to be a linear function of concentration over the range 0.005–0.1 mg kg−1 in each matrix. Mean overall recovery (n = 10) of nanafrocin varied from 71 to 101%. The results show that identification and quantification of nanafrocin residues in foodstuffs of animal origin can be successfully achieved by use of the proposed LC–MS–MS method.
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Ōmura S, Tanaka H, Koyama Y, Ōiwa R, Katagiri M, Awaya J, Nagai T, Hata T (1974) J Antibiot 27:363–365
Tanaka H, Koyama Y, Awaya J, Marumo H, Ōiwa R, Katagiri M, Nagai T, Ōmura S (1975) J Antibiot 28:860–867
Tanaka Y, Kamei K, Otoguro K, Ōmura S (1999) J Antibiot 52:880–888
Masuma R, Zhen DZ, Tanaka Y, Ōmura S (1990) J Antibiot 43:83–87
Tanaka Y, Masuma R, Ōmura S (1984) J Antibiot 37:1370–1375
Corcia AD, Nazzari M (2002) J Chromatogr A 974:53–89. doi:10.1016/S0021-9673(02)00905-6
Romero-González R, López-Martínez JC, Gómez-Milán E, Garrido-Frenich A, Martínez-Vidal JL (2007) J Chromatogr B 857:142–148. doi:10.1016/j.jchromb.2007.07.011
Balizs G, Hewitt A (2003) Anal Chim Acta 492:105–131. doi:10.1016/S0003-2670(03)00890-0
Hermo MP, Nemutlu E, Kır S, Barrón D, Barbosa J (2008) Anal Chim Acta 613:98–107. doi:10.1016/j.aca.2008.02.045
Kennedy DG, McCracken RJ, Cannavan A, Hewitt SA (1998) J Chromatogr A 812:77–98
Schneider MJ, Darwish AM, Freeman DW (2007) Anal Chim Acta 586:269–274
Petrović M, Hernando MD, Díaz-Cruz MS, Barceló D (2005) J Chromatogr A 1067:1–14
Shao B, Wu XY, Zhang J, Duan HJ, Chu XG, Wu YN (2009) Chromatographia 69:1083–1088. doi:10.1365/s10337-009-1009-z
Careri M, Bianchi F, Corradini C (2002) J Chromatogr A 970:3–64
Zimmer D (2003) Chromatographia 57:S325–S332. doi:10.1007/BF02492124
Clemente M, Hermo MP, Barrón D, Barbosa J (2006) J Chromatogr A 1135:170–178
Kitao C, Tanaka H, Minami S, Ōmura S (1980) J Antibiot 33:711–716
Moldes-Anaya AS, Asp TN, Eriksen GS, Skaar I, Rundberget T (2009) J Chromatogr A 1216:3812–3818
Castellari M, Gratacós-Cubarsí M, García-Regueiro JA (2009) J Chromatogr A 1216:8096–8100. doi:10.1016/j.chroma.2009.03.059
Galarini R, Fioroni L, Angelucci F, Tovo GR, Cristofani E (2009) J Chromatogr A 1216:8158–8164. doi:10.1016/j.chroma.2009.06.076
Peters RJB, Bolck YJC, Rutgers P, Stolker AAM, Nielen MWF (2009) J Chromatogr A 1216:8206–8216. doi:10.1016/j.chroma.2009.04.027
Llorca M, Farré M, Picó Y, Barceló D (2009) J Chromatogr A 1216:7195–7204. doi:10.1016/j.chroma.2009.06.062
Sala F, Zucchetti M, Bagnati R, D’Incalci M, Pace S, Capocasa F, Marangon E (2009) J Chromatogr B 877:3118–3126. doi:10.1016/j.jchromb.2009.08.001
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This work was supported by the Program of National Entry–Exit Inspection and Quarantine of China (No. 2007 B 884)
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Cheng, K., Wang, S., Guo, K. et al. Analysis of Nanafrocin in Foodstuffs of Animal Origin by LC–MS–MS. Chroma 71, 389–395 (2010). https://doi.org/10.1365/s10337-009-1449-5
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DOI: https://doi.org/10.1365/s10337-009-1449-5