Skip to main content
SpringerLink
Log in

GC–MS Method for Simultaneous Determination of Four Sedative Hypnotic Residues in Swine Tissues

  • Full Short Communication
  • Published:
Chromatographia Aims and scope Submit manuscript

Abstract

A robust, reliable and sensitive method is described for the simultaneous determination of diazepam, methaqualone, chlorpromazine and promethazine in swine muscle and liver tissues by GC–MS. The analytes were extracted with ethyl acetate and further clean-up performed with MCX solid-phase extraction cartridges. LODs and LOQs in the two tissues ranged from 0.2 to 0.3 μg kg−1 and 0.5 to 1 μg kg−1, respectively. Mean recoveries for the analytes ranged between 87.6 and 106.8%.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Dantzer R (1977) Vet Res Commun 1:161–169

    Article  CAS  Google Scholar 

  2. Wang LP, Zhao HX, Qiu YM (2006) J Chromatogr A 1136:99–105

    Article  CAS  Google Scholar 

  3. María LOC, Miguel HC (1999) J Chromatogr B 734:113–120

    Article  Google Scholar 

  4. Zhang GD, Terry AV, Bartlett MG (2007) J Chromatogr B 854:68–76

    Article  CAS  Google Scholar 

  5. Brenner C, Hui R, Passarelli J, Wu R, Brenneisen R, Bracher K, ElSohly MA, Ghodoussi VD, Salamone SJ (1996) Forensic Sci Int 79:31–41

    Article  CAS  Google Scholar 

  6. Plumb, Dondal C (2005) In: Plumb’s veterinary drug handbook, 5th edn. US

  7. Marleen L, Maria del MRF, Michelle W, Viviane M, Gert De B, Yvan V, Nele S (2007) Anal Bioanal Chem 388:1545–1556

    Article  Google Scholar 

  8. Shin MS, Philip M, Alex K (2004) Forensic Sci Int 143:87–101

    Article  Google Scholar 

  9. Quintana MC, Blanco MH, Lacal J (2003) Talanta 59:417–422

    Article  CAS  Google Scholar 

  10. The Ministry of Agriculture of the People’s Republic of China, Notification No. 235 of MOA, Maximum residue limits of veterinary drug residues in food of animal origin, (2002)

  11. Franz ED, Cornelia H, Thomas AB (2006) Int J Legal Med 120:323–330

    Article  Google Scholar 

  12. Michel Y, Frarqois M, Robert W (1997) Forensic Sci Int 84:211–218

    Article  Google Scholar 

  13. Mitona P, Simona P, Ester C (2007) J Pharm Biomed Anal 44:594–601

    Article  Google Scholar 

  14. Marion V, Marta C, Vincent C (2005) J Chromatogr B 825:72–78

    Article  Google Scholar 

  15. Hajime M, Kenji K, Kenji T (2006) Forensic Sci Int 157:57–70

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, 100193, Beijing, China

    Linli Cheng, Jianzhong Shen, Congming Wu & Suxia Zhang

  2. China Institute of Veterinary Drug Control, 100089, Beijing, China

    Yujie Zhang

Authors
  1. Linli Cheng
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yujie Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jianzhong Shen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Congming Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Suxia Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Suxia Zhang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cheng, L., Zhang, Y., Shen, J. et al. GC–MS Method for Simultaneous Determination of Four Sedative Hypnotic Residues in Swine Tissues. Chroma 71, 155–158 (2010). https://doi.org/10.1365/s10337-009-1403-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1365/s10337-009-1403-6

Keywords

Search

Navigation