Skip to main content
SpringerLink
Log in

LC–ESI–MS Determination of Flupentixol in Human Plasma

  • Full Short Communication
  • Published:
Chromatographia Aims and scope Submit manuscript

Abstract

Flupentixol and an internal standard, loperamide were extracted from human plasma by liquid–liquid extraction and analyzed on a Thermo Hypersil HyPURITY C18 column, with 10 mM ammonium acetate–acetonitrile–methanol (26:62:12, v/v/v) as mobile phase, coupled with electrospray ionization mass spectrometry (ESI–MS). The protonated analyte was quantified by selected-ion monitoring (SIM) with a quadrupole mass spectrometer in a positive-ion mode. The calibration curve was linear (r = 0.9990) over the concentration range: 0.039–2.5 ng mL−1. Intra-day and inter-day precision (RSD%) were less than 13.05%. The established method was successfully applied for the determination of pharmacokinetics of flupentixol in human plasma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Van Moffaert M, Dierick M, De Meulemeester F, Vereecken A (1983) Acta Psychiatr Belg 83:525–539

    Google Scholar 

  2. Shinozuka T, Terada M, Tanaka E (2006) Forensic Sci Int 162:108–112. doi:10.1016/j.forsciint.2006.03.038

    Article  CAS  Google Scholar 

  3. Chang D, Kolis SJ, Linderholm KH, Julian TF, Nachi R, Dzerk AM et al (2005) J Pharm Biomed Anal 38:487–496. doi:10.1016/j.jpba.2005.01.024

    Article  CAS  Google Scholar 

  4. Tanaka E, Terada M, Nakamura T (1997) J Chromatogr B Analyt Technol Biomed Life Sci 692:405–412. doi:10.1016/S0378-4347(96)00510-5

    Article  CAS  Google Scholar 

  5. Walter S, Bauer S, Roots I (1998) J Chromatogr B Analyt Technol Biomed Life Sci 720:231–237. doi:10.1016/S0378-4347(98)00432-0

    Article  CAS  Google Scholar 

  6. Kirchherr H, Kuhn-Velten WN (2006) J Chromatogr B Analyt Technol Biomed Life Sci 843:100–113. doi:10.1016/j.jchromb.2006.05.031

    Article  CAS  Google Scholar 

  7. Gutteck U, Rentsch KM (2003) Clin Chem Lab Med 41:1571–1579. doi:10.1515/CCLM.2003.240

    Article  CAS  Google Scholar 

  8. Weinmann W, Müller C, Vogt S, Frei A (2002) J Anal Toxicol 26:303–307

    CAS  Google Scholar 

  9. Che J, Meng Q, Chen Z, San C, Hou Y, Cheng Y (2007) J Pharm Biomed Anal 45:785–792. doi:10.1016/j.jpba.2007.07.022

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinical Pharmacy and Pharmacology Research Institute, Third Xiangya Hospital, Central South University, 410013, Changsha, China

    Xiao-Cong Zuo, Bi-Kui Zhang & Shi-Kun Liu

  2. Bioanalytical Chemistry Research Laboratory, Modern Analytical Test Center of Central South University, 410009, Changsha, China

    Ben-Mei Chen & Shao-Gang Liu

  3. Medical Laboratory Centre, Third Xiangya Hospital, Central South University, 410013, Changsha, China

    Guo-Ping Yang, Zhi-Jun Huang & Hong Yuan

  4. Chemical Industry College, Central South University, 410083, Changsha, China

    Shao-Qian Liu

Authors
  1. Xiao-Cong Zuo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bi-Kui Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ben-Mei Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shao-Gang Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Guo-Ping Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Shi-Kun Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Shao-Qian Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Zhi-Jun Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hong Yuan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hong Yuan.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zuo, XC., Zhang, BK., Chen, BM. et al. LC–ESI–MS Determination of Flupentixol in Human Plasma. Chroma 69, 301–305 (2009). https://doi.org/10.1365/s10337-008-0886-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1365/s10337-008-0886-x

Keywords

Search

Navigation