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Analysis and Stability Study of Octyl Nicotinate in Aqueous Solutions and Skin Homogenate by LC

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Abstract

Octyl nicotinate is an ester prodrug which is under development for delivery of nicotinic acid to skin for treatment and prevention of dermatological conditions that involve skin barrier impairment such as chronic photodamage and atopic dermatitis or for mitigating skin barrier impairment that results from therapy such as retinoids or steroids. We report here an isocratic RF-LC method with water/acetonitrile (10:90, v/v) as a mobile phase, for the rapid analysis of octyl nicotinate in aqueous solutions. The method was validated in terms of linearity, precision, accuracy and mean recovery of octyl nicotinate from skin homogenate ranging from 98.8 to 102.6%. Separation and quantification of amounts as low as 0.25 μg mL−1 octyl nicotinate was accomplished. The kinetic of degradation of octyl nicotinate in aqueous solution at 310, 333, 343, and 353 K was studied. The hydrolysis rate constants for degradation of octyl nicotinate in phosphate buffer and skin homogenate were reported. This method will be effective for routine analysis of octyl nicotinate stability in different formulations in future studies.

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References

  1. Tobin DJ (2006) Chem Soc Rev 35:52–67. doi:10.1039/b505793 k Medline

    Article  CAS  Google Scholar 

  2. Gilchrest BA (1996) Br J Dermatol 135(6):867–875. doi:10.1046/j.1365-2133.1996.d01-1088.x Medline

    Article  CAS  Google Scholar 

  3. Robert M, Bissonauth V, Ross G, Rouabhia M (1999) Int J Radiat Biol 75(3):317–326. doi:10.1080/095530099140492 Medline

    Article  CAS  Google Scholar 

  4. Kim D-W, Park J-Y, Na G-Y, Lee S-J, Lee W-J (2006) Int J Dermatol 45(6):698–701. doi:10.1111/j.1365-4632.2005.02644.x Medline

    Article  Google Scholar 

  5. Melnik B, Hollmann J, Plewig G (1988) Br J Dermatol 119(4):547–548. doi:10.1111/j.1365-2133.1988.tb03262.x Medline

    Article  CAS  Google Scholar 

  6. Tagami H, Tadaki T, Obata M, Koyama J (1992) Br J Dermatol 127(5):470–475. doi:10.1111/j.1365–2133.1992.tb14842.x Medline

    Article  CAS  Google Scholar 

  7. Kao JS, Fluhr JW, Man M-Q, Fowler AJ, Hachem J-P, Crumrine D, Ahn SK, Brown BE, Elias PM, Feingold KR (2003) J Invest Dermatol 120(3):456–464. doi:10.1046/j.1523–1747.2003.12053.x Medline

    Article  CAS  Google Scholar 

  8. Jacobson EL, Kim H, Kim M, Wondrak GT, Jacobson MK (2005) In: Alberts DS, Hess, Lisa M (eds) Fundamentals of cancer prevention, Springer-Verlag, Berlin Heidelberg, p 139

  9. Knopp RH, Ginsberg J, Albers JJ, Hoff C, Ogilvie JT, Warnick GR, Burrows E, Retzlaff B, Poole M (1985) Metabolism 34(7):642–650. doi:10.1016/0026-0495(85)90092-7 Medline

    Article  CAS  Google Scholar 

  10. Tashtoush BM, Qasem J, Williams JD, Dewald TP, Jacobson EL, Jacobson MK (2007) J Pharm Biomed Anal 43:893–899. doi:10.1016/j.jpba.2006.09.007 Medline

    Article  CAS  Google Scholar 

  11. Tashtoush BM, Kim H, Jacobson EL, Jacobson MK (2007) Drug Dev Ind Pharm 33(11):1176–1182. doi:10.1080/03639040701199274 Medline

    Article  CAS  Google Scholar 

  12. Hsu C-H, Jay M, Bummer PM, Lehmler H-J (2003) Pharm Res 20(6):918–925. doi:10.1023/A:1023899505837 Medline

    Article  CAS  Google Scholar 

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Acknowledgments

These studies were funded in part by Niadyne, Inc., and NIH grant R44 CA-90085. MKJ and ELJ are principals in Niadyne, Inc., whose sponsored research is managed in accordance with the University of Arizona conflict-of-interest policies.

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan

    Bassam M. Tashtoush

  2. Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan

    Amjad M. Qandil

  3. Department of Pharmacology and Toxicology, College of Pharmacy and Arizona Cancer Center, University of Arizona, Tucson, AZ, 85724, USA

    Elaine L. Jacobson & Myron K. Jacobson

Authors
  1. Bassam M. Tashtoush
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  2. Amjad M. Qandil
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  3. Elaine L. Jacobson
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  4. Myron K. Jacobson
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Correspondence to Bassam M. Tashtoush.

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Tashtoush, B.M., Qandil, A.M., Jacobson, E.L. et al. Analysis and Stability Study of Octyl Nicotinate in Aqueous Solutions and Skin Homogenate by LC. Chroma 68, 135–138 (2008). https://doi.org/10.1365/s10337-008-0659-6

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  • DOI: https://doi.org/10.1365/s10337-008-0659-6

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