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Application of Native and Hydroxypropyl-Substituted β-Cyclodextrin Bonded Silica Gel as Stationary Phases for High Performance Liquid Chromatography

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Abstract

Two chiral stationary phases for high-performance liquid chromatography (HPLC) have been synthesized by grafting native and 2-hydroxypropyl-β-cyclodextrin onto silica gel by a previously described method. They were tested under reversed-phase conditions. These two materials enable separation of the enantiomers of a variety of drugs (benzodiazepine anxiolytics, arylpropionic acids, anti-inflammatory and anticoagulant agents) and herbicides (aryloxyphenoxypropionic esters). Both chiral stationary phases enabled good chiral recognition in reversed-phase mode. The effects of the nature and composition of the mobile phase, of compound structure (mechanisms of chiral discrimination), and of flow-rate were studied.

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Authors and Affiliations

  1. Laboratoire d'Analyse Organique Fonctionnelle, Faculté de Chimie, U.S.T.H.B, BP 32 El Alia, Bab Ezzouar, 16111, Alger, Algeria

    K. Si Ahmed, F. Tazerouti & A. Y. Badjah-Hadj-Ahmed

  2. Centre de Recherche en Analyse Physico-Chimique, B.P. 248, Alger, RP, 16004, Algeria

    B. Y. Meklati

Authors
  1. K. Si Ahmed
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  2. F. Tazerouti
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  3. A. Y. Badjah-Hadj-Ahmed
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  4. B. Y. Meklati
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Corresponding author

Correspondence to F. Tazerouti.

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Revised: 7 July and 29 September 2005

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Ahmed, K.S., Tazerouti, F., Badjah-Hadj-Ahmed, A.Y. et al. Application of Native and Hydroxypropyl-Substituted β-Cyclodextrin Bonded Silica Gel as Stationary Phases for High Performance Liquid Chromatography. Chroma 62, 571–579 (2005). https://doi.org/10.1365/s10337-005-0673-x

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  • DOI: https://doi.org/10.1365/s10337-005-0673-x

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