Abstract
A simple and rapid LC method has been developed for the determination of coumarin 3-acyl derivatives synthesized and assayed for their inhibitory activity against monoamine oxidases (MAOs). The proposed liquid chromatography method can be used satisfactorily for the purity control of the synthesized compounds and can also be used to study the stability of these potentially reactive compounds. Moreover using this method it has been possible to elucidate the mechanism of MAO inhibition by direct determination of the biochemical reaction mixture.
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References
Dean FM (1963) Naturally occurring Oxygen Ring Compounds. Butterworth, London
Murray RDH, Mendez J, Brown SA (1982) The Natural Coumarins: Occurrence, Chemistry and Biochemistry. Wiley, New York
Meuly WC (1979) Kirk-Othmer Encyclopedia of Chemical Technology, 3rd ed/Vol.7. John Wiley and Sons, New York, p 196–206
Taylor WI, Chant B, Van Loveren G, (1979) Kirk-Othmer Encyclopedia of Chemical Tehnology, 3rd ed/Vol.4. John Wiley and Sons, New York, p 15
Maeda M (1994) Laser Dyes. Academy Press, New York
Hishmat OH, Miky JAA, Farrag AA, Fadl-Allah EM (1989) Arch Pharmacol Res 12:181–185
Nagesam M, Raju KM, Raju MS (1988) J Indian Chem Soc 65:380–382
Kashman Y, Gustafson KR, Fuller RW, Cardellina JH, McMahon JB, Currens MJ, Buckheit RW, Hughes SH, Gragg GM, Boyd MR (1992) J Med Chem 35:2735–2743
Tietze LF, Beifuss U (1991) Comprehensive Organic Synthesis, Pergamon Press, Oxford, 341–394; Rosen T, (1991) Comprehensive Organic Synthesis, Pergamon Press, Oxford, 395–408.
Bonsignore L, Loy G, Secci M, Cabiddu S, Gelli G (1988) J Chem Soc Perkin Trans II 1247–1250
Bonsignore L, Cottiglia F, Lavagna SM, Loy G, Secci D (1998) Farmaco 53: 693–697 and references cited therein
Chimenti F, Secci D, Bolasco A, Chimenti P, Granese A, Befani O, Turini P, Alcaro S, Ortuso F (2004) Bioorg Med Chem Lett 14: 3697–3703
Basford RE (1967) Methods in Enzymol 10: 96–101
Matsumoto T, Suzuki O, Furuta T, Asai M, Kurokawa Y, Rimura Y, Katsumata Y, Takahashi I (1985) Clin Biochem 18: 126–129
Bradford MM (1976) Anal Biochem 72:248–254
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Chimenti, F., Secci, D., Bolasco, A. et al. LC Determination of Coumarin-3-Acyl Derivatives for Evaluation of the Stability and Monoamine Oxidase Inhibition Mechanism. Chroma 61, 519–522 (2005). https://doi.org/10.1365/s10337-005-0534-7
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DOI: https://doi.org/10.1365/s10337-005-0534-7