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Synthesis of some coumarin derivatives and their antimicrobial activity

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Abstract

When 3-acetyl coumarin derivatives are treated with bromine, 3-(w-bromoacetyl) coumarin derivatives are obtained. The reaction of 3-(w-bromoacetyl) coumarin derivatives with thiourea or with amines for two hours leads to the formation of 2-Amino-4-(3-coumarinyl) thiazole or 3-(w-aminoacetyl) coumarin derivatives, respectively. While 3-(w-bromoacetyl) coumarin derivatives react with amines for 5–8 hours to yield imino derivatives of 3-(w-aminoacetyl) coumarin. The antimicrobial activity ofIa-b, IIa-c, IVc-f, IVh andVc, f, h, k, m, andq was studied.

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Authors and Affiliations

  1. National Research Center, Dokki, Cairo

    O. H. Hishmat & A. A. Farrag

  2. Faculty of Science, Al-Azhar University (girls), Cairo

    J. A. A. Miky

  3. Botany Department, Faculty of Science, Minia University, Minia, A. R. Egypt

    E. M. Fadl-Allah

Authors
  1. O. H. Hishmat
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  2. J. A. A. Miky
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  3. A. A. Farrag
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  4. E. M. Fadl-Allah
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Hishmat, O.H., Miky, J.A.A., Farrag, A.A. et al. Synthesis of some coumarin derivatives and their antimicrobial activity. Arch. Pharm. Res. 12, 181–185 (1989). https://doi.org/10.1007/BF02855551

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  • DOI: https://doi.org/10.1007/BF02855551

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