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Enantioselective Gas Chromatographic Analysis of Cyclopropane Derivatives

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Abstract

Chirasil-β-Dex was used as chiral stationary phase for the enantioselective gas chromatographic analysis of several new chiral cyclopropane derivatives. The GC method provides information about the chemical yields of the cyclopropane products, enantioselectivity, substrate specifity, and catalytic activity of the chiral catalysts used in the inter- and intra-molecular cyclopropanation reactions and avoids time-consuming work-up procedures.

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Acknowledgments.

The authors thank Professor Volker Schurig (University of Tübingen) for revising the manuscript. This work was supported by the Swiss National Science Foundation (Project No. 20-52581.97 and 2027048156) and by the European Commission for Science, Research and Development (COST Action D12). Thanks to the Swiss Chemical Society, Analytical Division for a travel grant awarded to A.G.

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Authors and Affiliations

  1. Department of Organic Chemistry, University of Geneva, Quai Ernest Ansermet 30, 1211, Geneva 4, Switzerland

    A. Ghanem, F. Lacrampe, S. Grass & P. Müller

  2. Pharmaceutical Analysis Laboratory, Biological and Medical Research Department (MBC-03), King Faisal Specialist Hospital and Research Center, Riyadh, 11211, Saudi Arabia

    A. Ghanem & H. Y. Aboul-Enein

  3. Institute of Organic Chemistry, University of Tübingen, Auf der Morgenstelle 18, 72076, Tübingen, Germany

    Z. Jiang

Authors
  1. A. Ghanem
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  2. H. Y. Aboul-Enein
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  3. F. Lacrampe
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  4. S. Grass
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  5. Z. Jiang
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  6. P. Müller
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Correspondence to A. Ghanem.

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Ghanem, A., Aboul-Enein, H., Lacrampe, F. et al. Enantioselective Gas Chromatographic Analysis of Cyclopropane Derivatives. Chroma 61, 103–111 (2005). https://doi.org/10.1365/s10337-004-0425-3

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  • DOI: https://doi.org/10.1365/s10337-004-0425-3

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