Abstract
An HPLC method was developed for the determination of S-carboxymethyl-L-cysteine, methylparaben and related compounds in cough syrup preparations. The HPLC operating conditions used were acetonitrile-methanol-water (120:280:600, V/V/V) pH adjusted to 4.0 with 0.1 M HCl, on a 5um Spherisorb ODS2 column (250 mm x 4.6 mm) with a flow rate of 1 mL min−1. The injection volume was 10 μL and absorbance was monitored at 210 nm with 0.05 a.u.f.s. sensitivity.
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Orlovic, D., Radulovic, D. & Vujic, Z. Determination of S-Carboxymethyl-L-Cysteine, Methylparaben and their Degradation Products in Syrup Preparations. Chromatographia 60, 329–333 (2004). https://doi.org/10.1365/s10337-004-0371-0
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DOI: https://doi.org/10.1365/s10337-004-0371-0