Abstract
The binding of psychopharmaceutical drugs by β-cyclodextrin (β-CD) changed their effective electrophoretic mobilities. Based on this phenomenon the interactions between some psychopharmaceutical drugs and β-cyclodextrin were studied and the binding constants of β-CD with tiapride, imipramine, clomipramine, amitriptyline, trifluoperazine, perphenazine and carbamazepine were determined by affinity capillary electrophoresis. The presence of β-CD improved the separation of these psychopharmaceutical drugs. Organic modifier was used as another kind of additive to be added in the running buffer to improve further the separation. 70 mM pH 7.2 phosphate buffer solution containing 12 mM β-cyclodextrin and 15% (v/v) acetone was selected as optimal running buffer for separation by capillary electrophoresis.
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Wei, W., Zhang, Z. & Ju, H. Study on Interactions of Several Psychopharmaceutical Drugs with β-Cyclodextrin by Affinity Capillary Electrophoresis and their Application in Separation. Chromatographia 59, 513–516 (2004). https://doi.org/10.1365/s10337-004-0193-0
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DOI: https://doi.org/10.1365/s10337-004-0193-0