Skip to main content
SpringerLink
Log in

The susceptibility gene for familial nasopharyngeal carcinoma is mapped on chromosome 4p11-p14 by haplotype analyses

  • Reports
  • Published:
Chinese Science Bulletin

Abstract

In our previous study, one candidate susceptibility locus for familial nasopharyngeal carcinoma (NPC) has been defined to a 14.21-cM region on 4p15.1-q12, whereas the distal minimum boundary of this region remained to be further determined in respect that the two markers D4S2996 and D4S428 were uninformative. In the present study, we carried out a haplotype analysis to identify the exact boundary by using the combination of a set of microsatellite markers and single nucleotide polymorphism (SNP) markers in two major NPC families. We defined the exact distal boundary between D4S1577 and D4S3347, and consequently shortened the susceptibility locus to an 8.29-cM segment on 4p11–p14.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Lu, S. J., Day, N. E., Degos, L. et al., Linkage of a nasopharyngeal carcinoma susceptibility locus to the HLA region, Nature, 1990, 346: 470–471.

    Article  Google Scholar 

  2. Feng, B. J., Huang, W., Shugart, Y. Y. et al., Genome-wide scan for familial nasopharyngeal carcinoma and evidence for linkage to chromosome 4, Nat. Genet., 2002, 31: 395–399.

    Google Scholar 

  3. Beghini, A., Tibiletti, M., Roversi, G. et al., Germline mutation in the juxtamembrane domain of the KIT gene in a family with gastrointestinal stromal tumors and urticaria pigmentosa, Cancer, 2001, 92: 657–662.

    Article  Google Scholar 

  4. Walter, J. W., North, P. E., Waner, M. et al., Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma, Genes Chromosomes Cancer, 2002, 33: 295–303.

    Article  Google Scholar 

  5. Heinrich, M. C., Corless, C. L., Duensing, A. et al., PDGFRA activating mutations in gastrointestinal stromal tumors, Science, 2003, 299: 708–710.

    Article  Google Scholar 

  6. Asanoma, K., Matsuda, T., Kondo, H. et al., NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif small star, filled, Genomics, 2003, 81: 15–25.

    Article  Google Scholar 

  7. Xi, H. F., Ke, Y. H., Xiao, J. H. et al., Linkage analysis on chromosome 2 in essential hypotension pedigrees, Chin. Sci. Bull., 47(18): 1538–1540.

  8. Tan, W., Wu, J. X., Tang, H. J. et al., Expression of cytochrome P450 2E1 in human liver: Relationship between genotype and phenotype in Chinese, Science in China, Ser. C, 2001, 44(4): 356–364.

    Article  Google Scholar 

  9. Emahazion, T., Feuk, L., Jobs, M. et al., SNP association studies in Alzheimer’s disease highlight problems for complex disease analysis, Trends Genet., 2001, 17(7): 407–13.

    Article  Google Scholar 

  10. Collins, F. S., Brooks, L. D., Chakravarti, A., A DNA polymorphism discovery resource for research on human genetic variation, Genome Res., 1998, 8: 1229–1231.

    Google Scholar 

  11. Sachidanandam, R., Weissman, D., Schmidt, S. C. et al., Map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms, Nature, 2001, 409: 928–933.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cancer Center, Sun Yet-sun University, 510060, Guangzhou, China

    Hankui Chen, Bingjian Feng, Hui Liang, Ruhua Zhang & Yixin Zeng

Authors
  1. Hankui Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bingjian Feng
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hui Liang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ruhua Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yixin Zeng
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yixin Zeng.

About this article

Cite this article

Chen, H., Feng, B., Liang, H. et al. The susceptibility gene for familial nasopharyngeal carcinoma is mapped on chromosome 4p11-p14 by haplotype analyses. Chin.Sci.Bull. 48, 2328–2331 (2003). https://doi.org/10.1360/03wc0298

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1360/03wc0298

Keywords

Search

Navigation