Avoid common mistakes on your manuscript.
Past
The role of the urinary microbiome in developing and course of bladder cancer remains a matter of debate. Previous investigations had primarily focused on comparing urine microbiome composition between patients with and without evidence of tumor, overlooking the specific alterations induced by the transurethral resection of the bladder tumor (TURBT).1 Additionally, the unexplored territory of the tumor-associated microbiome remains understudied and its comparison to the microbiome detected in urine requires further studies, also regarding the urine method collection.2,3 Our study addressed the changes in the urinary microbiome after transurethral resection of non-muscle-invasive bladder cancer (NMIBC) and the characteristics of tumor tissue microbiome.4
Present
Our findings revealed dynamic shifts in the bladder microbiome of low-grade Ta papillary NMIBC patients following TURBT. Notably, the phylogenetic diversity of the urine microbiome decreased at the 1-year follow-up, with distinct taxa enrichment compared with the time of index resection. Actinomyces, Candidatus, Sphingobacterium, Sellimonas, Fusobacterium, and Roseobacter were identified as the most differentially enriched taxa in the urine at follow-up. Furthermore, the tumor tissue microbiome displayed greater phylogenetic diversity than paired urine samples with enrichment of Acinetobacter and Sphingomonas taxa. Moreover, specific bacterial taxa are enriched in patients who will develop recurrence, namely Corynebacterium and Anaerococcus could serve as potential prognostic factors for future recurrence.
Future
The implications of our study underscore the need for further research to unravel the interplay between bladder microbiome, tumor microbiome, and their alterations. Elucidating the predictive value of these microbiome changes could pave the way for personalized therapeutic interventions. Future studies should delve into the development of probiotic drugs, offering a targeted approach to modulate microbial communities and enhance antitumor immunity. A comprehensive understanding of the urinary microbiome's intricate relationship with disease recurrence and progression holds promise for more effective and personalized therapeutic strategies in the management of NMIBC.
References
Hussein AA, Bhat TA, Jing Z, Gomez EC, Wasay MA, Singh PK, et al. Does the urinary microbiome profile change after treatment of bladder cancer? World J Urol. 2023;41(12):3593–8. https://doi.org/10.1007/s00345-023-04627-1.
Mansour B, Monyók Á, Makra N, Gajdács M, Vadnay I, Ligeti B, et al. Bladder cancer-related microbiota: examining differences in urine and tissue samples. Sci Rep. 2020;10(1):11042.
Pederzoli F, Ferrarese R, Amato V, Locatelli I, Alchera E, Lucianò R, et al. Sex-specific alterations in the urinary and tissue microbiome in therapy-naïve urothelial bladder cancer patients. Eur Urol Oncol. 2020;3(6):784–8.
Ślusarczyk A, Ismail H, Zapała Ł, Piecha T, Zapała P, Radziszewski P. Changes in the urinary microbiome after transurethral resection of non-muscle-invasive bladder cancer: insights from a prospective observational study. Ann Surg Oncol. 2024. https://doi.org/10.1245/s10434-024-15198-9.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Disclosure
No conflict of interest to declare.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This article refers to: Ślusarczyk A, Ismail H, Zapała Ł, Piecha T, Zapała P, Radziszewski P. Changes in the urinary microbiome after transurethral resection of non-muscle-invasive bladder cancer: insights from a prospective observational study. Annals Surgical Oncology. (2024). https://doi.org/10.1245/s10434-024-15198-9.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Ślusarczyk, A. ASO Author Reflections: Changes in the Urinary Microbiome After Transurethral Resection of Nonmuscle-Invasive Bladder Cancer: Insights from a Prospective Observational Study. Ann Surg Oncol 31, 3910–3911 (2024). https://doi.org/10.1245/s10434-024-15248-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1245/s10434-024-15248-2