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Past
Esophageal cancer has the sixth highest cancer mortality in the world. A majority of esophageal adenocarcinomas occur in developed countries, and esophageal squamous carcinomas (ESCCs) predominate in low-income countries, especially in China, where 90% are squamous carcinomas.1 The 5-year mortality rate of ESCCs is 30–40%, and the current clinical treatment is mainly based on radiotherapy and chemotherapy.2 Small molecule drugs have been rapidly developed in recent years, but they are less selective for ESCCs.
Present
COL8A1 was screened by tissue microarrays as a significantly highly expressed molecule in ESCC tissues, even though it was a nonindependent factor. However, it was found through cell and animal experiments that COL8A1 could regulate the proliferation and invasion of ESCCs through PI3K/AKT pathway activation.3 Resultingly, we believe that COL8A1 is a tumor marker or a key regulator of pathogenesis in ESCCs that deserves further investigation.
Future
COL8A1 (collagen type VIII alpha 1 chain), a secreted protein, is a promising tumor-promoting molecule whose role in gastrointestinal digestive system tumors has been partially reported,4,5 but not in ESCC. COL8A1 is predominantly distributed in the interstitial space of the cells, so COL8A1-mediated invasion of ESCC may be mediated by COL8A1 through the regulating intercellular communication, EMT transformation, or cell junction effects. Therefore, COL8A1-mediated tumor invasion and migration is a future research direction.
References
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. https://doi.org/10.3322/caac.21492.
Niu C, Liu Y, Wang J, et al. Risk factors for esophageal squamous cell carcinoma and its histological precursor lesions in China: a multicenter cross-sectional study. BMC Cancer. 2021;21(1):1034. https://doi.org/10.1186/s12885-021-08764-x.
Jing H, Pengbo L, Yanggang D, Zhe Ch, Yeting L, Xue Ch, Senxiang Y. COL8A1 Regulates Esophageal Squamous Carcinoma Proliferation and Invasion through PI3K/AKT Pathway. Ann Surg Oncol. 2023. https://doi.org/10.1245/s10434-023-14370-x.
Yan B, Liu L, Zhao L, et al. Tumor and stroma COL8A1 secretion induces autocrine and paracrine progression signaling in pancreatic ductal adenocarcinoma. Matrix Biol. 2022;114:84–107. https://doi.org/10.1016/j.matbio.2022.11.002.
Zhang L, Jiang X, Li Y, et al. Clinical correlation of Wnt2 and COL8A1 with colon adenocarcinoma prognosis. Front Oncol. 2020;10:1504. https://doi.org/10.3389/fonc.2020.01504.
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This article refers to: Jing H, Pengbo L, Yanggang D et al. COL8A1 Regulates Esophageal Squamous Carcinoma Proliferation and Invasion through PI3K/AKT Pathway. Annals Surgical Oncology. (2023). https://doi.org/10.1245/s10434-023-14370-x.
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Hu, J., Yan, S. ASO Author Reflections: COL8A1 Regulates Esophageal Squamous Carcinoma. Ann Surg Oncol 31, 3033 (2024). https://doi.org/10.1245/s10434-023-14433-z
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DOI: https://doi.org/10.1245/s10434-023-14433-z