Abstract
Background
The 2015 American Thyroid Association guidelines endorsed lobectomy for patients with low-risk papillary thyroid cancer (PTC) measuring 1–4 cm. Attitudes about the use of lobectomy for these patients are lacking, particularly from low-volume surgeons who perform the majority of thyroidectomies in the US.
Methods
A survey was mailed to 1000 surgeons stratified by specialty (500 general surgeons and 500 otolaryngologists) registered with the American Medical Association, to evaluate beliefs and practices about the extent of surgery for low-risk PTC. Comparisons examined differences by surgeon volume.
Results
Of 320 respondents who have performed thyroidectomy since 2015 (150 general surgeons, 170 otolaryngologists), 206 (64.4%) were low volume (< 26 thyroidectomies/year). The proportion of surgeons recommending lobectomy for low-risk PTC measuring 1.1 to < 4 cm ranged from 43.1 to 2.6%. High-volume surgeons recommended lobectomy more frequently for PTC measuring 1.1–3 cm, although this was not statistically significant. Thirty-three percent of respondents believed lobectomy is underused for low-risk PTC, while 10.0% believed it is overused. Additionally, 19.6% of respondents believed recurrence is more likely after lobectomy than total thyroidectomy, and 3.3% believed mortality is higher. Few believed quality of life is better after lobectomy (12.3%). Low-volume surgeons were less likely to be aware guidelines support lobectomy for low-risk PTC 1–4 cm (p < 0.001) and less likely to use clinical practice guidelines (p = 0.004).
Conclusions
Most surgeons do not support lobectomy for patients with low-risk PTC > 1 cm. Awareness of guidelines and concerns about increased risk of recurrence after lobectomy may drive surgeons’ preference for total thyroidectomy.
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References
McDow AD, Pitt SC. Extent of surgery for low-risk differentiated thyroid cancer. Surg Clin North Am. 2019;99(4):599–610.
Bilimoria KY, Bentrem DJ, Ko CY, et al. Extent of surgery affects survival for papillary thyroid cancer. Ann Surg. 2007;246(3):375–81. (discussion 381-374).
Adam MA, Pura J, Gu L, et al. Extent of surgery for papillary thyroid cancer is not associated with survival: an analysis of 61,775 patients. Ann Surg. 2014;260(4):601–5. (discussion 605-607).
Mendelsohn AH, Elashoff DA, Abemayor E, St John MA. Surgery for papillary thyroid carcinoma: is lobectomy enough? Arch Otolaryngol Head Neck Surg. 2010;136(11):1055–61.
Nixon IJ, Ganly I, Patel SG, et al. Thyroid lobectomy for treatment of well differentiated intrathyroid malignancy. Surgery. 2012;151(4):571–9.
Gartland RM, Lubitz CC. Impact of extent of surgery on tumor recurrence and survival for papillary thyroid cancer patients. Ann Surg Oncol. 2018;25(9):2520–5.
Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26(1):1–133.
Adam MA, Thomas S, Youngwirth L, et al. Is there a minimum number of thyroidectomies a surgeon should perform to optimize patient outcomes? Ann Surg. 2017;265(2):402–7.
Jensen C, Roman B, Brito JP, Saucke MC, Zaborek N, Jennings JL, Pitt SC. Barriers to active surveillance: a survey of endocrinologists and surgeons. Thyroid. 2018;28(S1):P1-A158.
Saucke MC, Roman BR, Zaborek N, Jensen C, Jennings JL, Pitt SC. Treatment recommendations for low-risk thyroid cancer: are patients’ or providers’ preferences more important? Medical decision making. 2018;38(1):E1–343.
Fowler FJ Jr, McNaughton Collins M, Albertsen PC, Zietman A, Elliott DB, Barry MJ. Comparison of recommendations by urologists and radiation oncologists for treatment of clinically localized prostate cancer. JAMA. 2000;283(24):3217–22.
Gharib H, Papini E, Garber JR, et al. American Association of Clinical Endocrinologists, American College of Endocrinology, and Associazione Medici Endocrinologi Medical Guidelines for clinical practice for the diagnosis and management of thyroid nodules—2016 update. Endocr Pract. 2016;22(5):622–39.
Network NCC. Thyroid Carcinoma (Version 1.2017). 2017. https://www.nccn.org/patients/guidelines/content/PDF/thyroid-patient.pdf. Accessed 2018.
Wang TS, Goffredo P, Sosa JA, Roman SA. Papillary thyroid microcarcinoma: an over-treated malignancy? World J Surg. 2014;38(9):2297–303.
Adam MA, Pura J, Goffredo P, et al. Impact of extent of surgery on survival for papillary thyroid cancer patients younger than 45 years. J Clin Endocrinol Metab. 2015;100(1):115–21.
Or K, Benbassat C, Koren S, et al. Adherence to ATA 2015 guidelines in the management of unifocal non-invasive papillary thyroid cancer: a clinical survey among endocrinologists and surgeons. Eur Arch Otorhinolaryngol. 2018;275(11):2851–9.
van Gerwen M, Alsen M, Lee E, Sinclair C, Genden E, Taioli E. Recurrence-free survival after total thyroidectomy and lobectomy in patients with papillary thyroid microcarcinoma. J Endocrinol Invest. 2021;44(4):725–34.
Rosato L, Pacini F, Panier Suffat L, et al. Post-thyroidectomy chronic asthenia: self-deception or disease? Endocrine. 2015;48(2):615–20.
Li J, Xue LB, Gong XY, et al. Risk factors of deterioration in quality of life scores in thyroid cancer patients after thyroidectomy. Cancer Manag Res. 2019;11:10593–8.
Nickel B, Tan T, Cvejic E, et al. Health-related quality of life after diagnosis and treatment of differentiated thyroid cancer and association with type of surgical treatment. JAMA Otolaryngol Head Neck Surg. 2019;145(3):231–8.
Ryu J, Ryu YM, Jung YS, et al. Extent of thyroidectomy affects vocal and throat functions: a prospective observational study of lobectomy versus total thyroidectomy. Surgery. 2013;154(3):611–20.
Hauch A, Al-Qurayshi Z, Randolph G, Kandil E. Total thyroidectomy is associated with increased risk of complications for low- and high-volume surgeons. Ann Surg Oncol. 2014;21(12):3844–52.
Orosco RK, Lin HW, Bhattacharyya N. Ambulatory thyroidectomy: a multistate study of revisits and complications. Otolaryngol Head Neck Surg. 2015;152(6):1017–23.
Acknowledgment
This study was funded by the University of Wisconsin Carbone Cancer Center Support Grant P30 CA014520. Dr. Pitt is supported by the National Cancer Institute of the National Institutes of Health (NIH) award number K08CA230204. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. In addition, the NIH did not play a role in the design or conduct of the study; data collection, management, analysis or interpretation; manuscript preparation, review, or approval; and decision to submit the manuscript for publication. The authors would like to acknowledge Margarete Wichman, PhD, Griselle Sanchez-Diettert, BA, and Kelly M. Elver, PhD, from the University of Wisconsin Survey Center for their assistance with survey preparation and critical review.
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McDow, A.D., Saucke, M.C., Marka, N.A. et al. Thyroid Lobectomy for Low-Risk Papillary Thyroid Cancer: A National Survey of Low- and High-Volume Surgeons. Ann Surg Oncol 28, 3568–3575 (2021). https://doi.org/10.1245/s10434-021-09898-9
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DOI: https://doi.org/10.1245/s10434-021-09898-9