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Prognostic Implication of Postoperative Weight Loss After Esophagectomy for Esophageal Squamous Cell Cancer

  • Thoracic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Preoperative weight loss in esophageal cancer is reported to be associated with a poor prognosis. However, the impact of postoperative weight loss on the prognosis of patients with esophageal cancer remains unclear.

Methods

This study included 186 patients with esophageal squamous cell carcinoma who underwent surgery between January 2012 and January 2015. The relationship between weight loss 6 months after esophagectomy as well as the clinical factors and prognosis of patients was investigated.

Results

The mean weight loss rate for all the patients was 9.3% at 3 months, 10.8% at 6 months, 11.1% at 12 months, and 11.4% at 24 months after surgery. The patients with severe weight loss 6 months after surgery (≥ 12%) exhibited lower serum albumin levels and a lower prognostic nutrition index 6 months after esophagectomy than the patients with moderate weight loss (< 12%; p = 0.011 and 0.009, respectively). Although overall survival did not differ significantly between the two groups, for all the patients, severe weight loss was significantly associated with shortened overall survival for the cStages 3 and 4 patients (3-year overall survival rate, 76.6% in the moderate group vs 54.5% in the severe group; p = 0.042). The multivariate analyses identified only severe weight loss as an independent factor associated with worse overall survival for the cStages 3 and 4 patients (p = 0.034).

Conclusion

This study showed that postoperative weight loss negatively affected the prognosis for patients with advanced esophageal cancer, indicating the necessity of administering nutritional interventions to these patients to prevent postoperative weight loss.

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Authors and Affiliations

  1. Department of Digestive Surgery, Osaka International Cancer Institute, Osaka, Japan

    Yuto Kubo MD, Hiroshi Miyata MD, Keijiro Sugimura MD, Naoki Shinno MD, Kei Asukai MD, Shinitiro Hasegawa MD, Yoshitomo Yanagimoto MD, Daisaku Yamada MD, Kazuyoshi Yamamoto MD, Junichi Nishimura MD, Hiroshi Wada MD, Hidenori Takahashi MD, Masayoshi Yasui MD, Takeshi Omori MD, Masayuki Ohue MD & Masahiko Yano MD

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  1. Yuto Kubo MD
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Correspondence to Hiroshi Miyata MD.

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Kubo, Y., Miyata, H., Sugimura, K. et al. Prognostic Implication of Postoperative Weight Loss After Esophagectomy for Esophageal Squamous Cell Cancer. Ann Surg Oncol 28, 184–193 (2021). https://doi.org/10.1245/s10434-020-08762-6

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  • DOI: https://doi.org/10.1245/s10434-020-08762-6

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