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The Landmark Series: Intrahepatic Cholangiocarcinoma

  • Hepatobiliary Tumors
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Introduction

Intrahepatic cholangiocarcinoma (ICC) is an aggressive biliary tract cancer (BTC) with distinct anatomic, molecular, and clinical characteristics that distinguishes it from other BTCs.

Methods

In this landmark series review, we highlight the critical studies that have defined the surgical management of ICC, as well as several randomized controlled trials that have investigated adjuvant therapy strategies.

Results

Surgical resection is the mainstay of treatment and should involve margin-negative resection with regional lymphadenectomy. Several recently completed and ongoing randomized controlled trials are defining the indications for adjuvant therapy among patients with resected ICC.

Conclusions

In the near future, improved understanding of the molecular features of ICC should lead to newer targeted therapies as well as a more personalized approach to systemic therapy.

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Authors and Affiliations

  1. Department of Surgery, The Ohio State University, Columbus, OH, USA

    Jordan M. Cloyd MD, Aslam Ejaz MD, MPH & Timothy M. Pawlik MD, MPH, MTS, PhD

  2. Department of Surgery, Oncology, The Urban Meyer III and Shelley Meyer Chair for Cancer Research, Health Services Management and Policy, The Ohio State University, Wexner Medical Center, Columbus, OH, USA

    Timothy M. Pawlik MD, MPH, MTS, PhD

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  1. Jordan M. Cloyd MD
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Correspondence to Timothy M. Pawlik MD, MPH, MTS, PhD.

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Cloyd, J.M., Ejaz, A. & Pawlik, T.M. The Landmark Series: Intrahepatic Cholangiocarcinoma. Ann Surg Oncol 27, 2859–2865 (2020). https://doi.org/10.1245/s10434-020-08621-4

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  • DOI: https://doi.org/10.1245/s10434-020-08621-4

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