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Role of Prealbumin as a Powerful and Simple Index for Predicting Postoperative Complications After Gastric Cancer Surgery

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Preoperative factors, including nutritional status, may have strong correlations with postoperative morbidities. The current study evaluated preoperative prealbumin concentrations as a predictor of postoperative complications after gastric surgery.

Methods

A retrospective study of 1798 patients who underwent gastrectomy for gastric adenocarcinoma was performed. Information was collected on basic patient characteristics, preoperative laboratory findings, and 30 day postoperative complications. The patients were divided into three groups based on prealbumin concentrations (≥22 mg/dL, <22 to ≥15 mg/dL, and <15 mg/dL) for analysis.

Results

The overall complication rate was 21.7 %, and the infection rate was 16 %. Subgroup analysis based on prealbumin concentrations showed that complication rates were markedly elevated with decreasing concentrations of prealbumin. Multivariate analysis using a logistic regression model showed that both overall and infectious complications were strongly associated with male gender, elevated C-reactive protein (CRP), and decreased prealbumin levels (p < 0.05). Even in patients with a CRP level higher than 0.1 mg/dL, male gender and low prealbumin concentrations (<15 mg/dL) were significantly correlated with overall and infectious morbidities (p < 0.05).

Conclusions

Preoperative prealbumin concentrations are useful predictors of short-term postoperative outcomes after gastrectomy.

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Authors and Affiliations

  1. Department of Gastroenterological Surgery, Cancer Institute Hospital, Gastroenterological Center, Japanese Foundation for Cancer Research, Tokyo, Japan

    J. Zhou MD, PhD, N. Hiki MD, PhD, S. Mine MD, PhD, K. Kumagai MD, PhD, S. Ida MD, PhD, X. Jiang MD, PhD, S. Nunobe MD, PhD, M. Ohashi MD, PhD, T. Sano MD, PhD & T. Yamaguchi MD, PhD

  2. Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China

    J. Zhou MD, PhD

  3. Department of Gastroenterological Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China

    X. Jiang MD, PhD

Authors
  1. J. Zhou MD, PhD
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  2. N. Hiki MD, PhD
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  3. S. Mine MD, PhD
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  4. K. Kumagai MD, PhD
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  5. S. Ida MD, PhD
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  6. X. Jiang MD, PhD
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  7. S. Nunobe MD, PhD
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  8. M. Ohashi MD, PhD
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  9. T. Sano MD, PhD
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  10. T. Yamaguchi MD, PhD
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Corresponding author

Correspondence to N. Hiki MD, PhD.

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Zhou, J., Hiki, N., Mine, S. et al. Role of Prealbumin as a Powerful and Simple Index for Predicting Postoperative Complications After Gastric Cancer Surgery. Ann Surg Oncol 24, 510–517 (2017). https://doi.org/10.1245/s10434-016-5548-x

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  • DOI: https://doi.org/10.1245/s10434-016-5548-x

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