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Advanced Gastric Cancer with Early Cancer Macroscopic Appearance: Is It Worthy of D2 Lymphadenectomy?

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Previous studies report that 5.9–22.2% of patients with preoperatively diagnosed early gastric cancers were eventually proven to have advanced gastric cancers by postoperative pathological examination. Such misdiagnosed cases commonly had cancers with macroscopic appearance like early gastric cancer and consequently can be recognized as a subgroup of cancer, namely advanced gastric cancer with early cancer macroscopic appearance (eAGC). Theoretically eAGCs might require D2 lymphadenectomy, but frequently undergo limited lymphadenectomy. However, the validity of the limited surgery is still unclear.

Methods

Clinicopathologic features of 134 patients with eAGC were retrospectively reviewed and compared with those of patients with early gastric cancers and advanced gastric cancers, respectively.

Results

Clinicopathologic features of eAGCs were similar to those of submucosa cancers, but significantly different from those of mucosa cancers and other muscularis propria cancers. Tumor size, lymphatic and/or blood vessels invasion (LBVI), and depth of invasion were identified as independent factors predicting lymph node metastasis; however, postoperative stage was not. All patients with eAGCs were proven to have lymph node metastasis restricted to the perigastric lymph nodes and lymph nodes at stations 7, 8a, and 9. Age, LBVI, and depth of invasion were independent prognostic factors for patients with preoperatively diagnosed early gastric cancers; however, the misdiagnosis of early cancer and the option of lymphadenectomy (D2 or not D2) had no impact on patient survival. The incidence of recurrence of eAGCs was similar to that of submucosa cancers, but significantly different from that of mucosa cancers and other muscularis propria cancers.

Conclusions

Modified gastrectomy B (dissection of perigastric lymph nodes and nodes at stations 7, 8a, and 9) might be recommended for patients with eAGCs.

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Acknowledgment

Supported by grants from the National Natural Science Foundation of China (no. 30901419).

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Authors and Affiliations

  1. Department of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China

    Zhe Sun MD, Zhen-ning Wang MD, Guo-lian Zhu MD, Bao-jun Huang MD, Kai Li MD, Yan Xu MD, De-ming Li MD & Hui-mian Xu MD

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  1. Zhe Sun MD
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  2. Zhen-ning Wang MD
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  3. Guo-lian Zhu MD
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  4. Bao-jun Huang MD
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  5. Kai Li MD
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  6. Yan Xu MD
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  8. Hui-mian Xu MD
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Correspondence to Hui-mian Xu MD.

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Sun, Z., Wang, Zn., Zhu, Gl. et al. Advanced Gastric Cancer with Early Cancer Macroscopic Appearance: Is It Worthy of D2 Lymphadenectomy?. Ann Surg Oncol 17, 1278–1290 (2010). https://doi.org/10.1245/s10434-009-0890-x

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  • DOI: https://doi.org/10.1245/s10434-009-0890-x

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