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Intra-Individual Comparison of Lymphatic Drainage Patterns Using Subareolar and Peritumoral Isotope Injection for Breast Cancer

  • Breast Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Controversy exists in the literature regarding the optimal site for lymphatic mapping in breast cancer. This study was designed to characterize lymphatic drainage patterns within the same patient after subareolar (SA) and peritumoral (PT) radiopharmaceutical injections and examine the impact of reader interpretation on reported drainage.

Methods

In this prospective trial, 27 women with breast cancer underwent sequential preoperative SA and PT injections of 0.5 to 2.7 mCi of technetium-99 m filtered sulfur colloid 3 days or more apart. Patterns of radiopharmaceutical uptake were reviewed independently by two nuclear medicine physicians. Inter-reader agreement and injection success were assessed in conjunction with observed drainage patterns.

Results

There was near perfect inter-reader agreement observed on identification of axillary LN drainage after PT injection (P = 0.0004) and substantial agreement with SA injection (P = 0.0344). SA injection was more likely to drain to only axillary LNs, whereas PT injection appeared more likely to drain to both axillary and extra-axillary LNs, although no statistically significant differences were found. All patients with extra-axillary drainage after PT injection (n = 6 patients) had only axillary drainage after SA injection. Dual drainage was observed for six patients with PT injection and one patient with SA injection.

Conclusions

Our findings suggest that radiopharmaceutical injected in the SA location has a high propensity to drain to axillary LNs only. After controlling for patient factors and demonstrating inter-reader agreement, the inability to demonstrate statistically significant differences in drainage based on injection site suggests that lymphatic drainage patterns may be a function of patient and tumor-specific features.

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Acknowledgment

Research supported by funding from NIH Avon Supplement 3 P30 CA16672-29S (to G.V. Babiera).

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Authors and Affiliations

  1. Department of Plastics-Reconstructive Surgery, Duke University School of Medicine, Durham, NC, USA

    Regina M. Fearmonti MD, Isabelle Bedrosian MD, Kelly K. Hunt MD, Funda Meric-Bernstam MD, Barry Feig MD, Elham Ghonimi MD & Gildy V. Babiera MD

  2. Department of Nuclear Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

    Isis W. Gayed MD & Edmund Kim MD

  3. Department of Biostatistics and Applied Mathematics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

    Carla Warneke MS

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  1. Regina M. Fearmonti MD
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  2. Isis W. Gayed MD
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  3. Edmund Kim MD
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  10. Gildy V. Babiera MD
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Correspondence to Gildy V. Babiera MD.

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Fearmonti, R.M., Gayed, I.W., Kim, E. et al. Intra-Individual Comparison of Lymphatic Drainage Patterns Using Subareolar and Peritumoral Isotope Injection for Breast Cancer. Ann Surg Oncol 17, 220–227 (2010). https://doi.org/10.1245/s10434-009-0633-z

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  • DOI: https://doi.org/10.1245/s10434-009-0633-z

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