Skip to main content

Advertisement

SpringerLink
Log in

Clinicopathologic Characteristics and Prognosis for Young Gastric Adenocarcinoma Patients after Curative Resection

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Conflicting results from previous studies on gastric adenocarcinoma (GC) in young patients have led to controversy surrounding the prognosis for young GC patients.

Methods

The authors studied 6954 patients with GC who received curative resections. They were classified into three groups: those aged 40 years or less (“young,” 12.7%); those aged 41–65 years (“middle-aged,” 66.7%); and those aged more than 65 years (“elderly,” 20.6%). Clinicopathologic characteristics and overall survival rates were analyzed.

Results

Young patients were predominately female and had tumors that were histologically undifferentiated. However, in regard to T4 invasion, N3 lymph node metastasis, and TNM stage IV, the characteristics of the tumors of young patients were similar to those of middle-aged and elderly patients. Overall survival rate was significantly better in young patients than middle-aged patients (P = .018) and elderly patients (P < .001). Stratified by TNM stage, young patients showed better overall survival at stage I than middle-aged patients, and at stages I, II, and IIIa than elderly patients. Multivariate analysis indicated that age was an independent prognostic factor (as well as gender, operation type, depth of invasion, and lymph node status).

Conclusions

The predominance of female cases and tumors that were histologically undifferentiated were distinctive characteristics in young patients. Young patients could gain a survival benefit after curative resection with stage I disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.

Similar content being viewed by others

References

  1. Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55:74–108

    PubMed  Google Scholar 

  2. Lee HJ, Yang HK, Ahn YO. Gastric cancer in Korea. Gastric Cancer 2002; 5:177–82

    Article  PubMed  Google Scholar 

  3. Kunisaki C, Akiyama H, Nomura M, et al. Clinicopathological features of gastric carcinoma in younger and middle-aged patients: a comparative study. J Gastrointest Surg 2006; 10:1023–32

    Article  PubMed  Google Scholar 

  4. Koea JB, Karpeh MS, Brennan MF. Gastric cancer in young patients: demographic, clinicopathological, and prognostic factors in 92 patients. Ann Surg Oncol 2000; 7:346–51

    Article  PubMed  CAS  Google Scholar 

  5. Theuer CP, Kurosaki T, Taylor TH, et al. Unique features of gastric carcinoma in the young: a population-based analysis. Cancer 1998; 83:25–33

    Article  PubMed  CAS  Google Scholar 

  6. Katai H, Sasako M, Sano T, et al. Gastric carcinoma in young adults. Jpn J Clin Oncol 1996; 26:139–43

    PubMed  CAS  Google Scholar 

  7. Ramos-De la Medina A, Salgado-Nesme N, Torres-Villalobos G, et al. Clinicopathologic characteristics of gastric cancer in a young patient population. J Gastrointest Surg 2004; 8:240–4

    Article  PubMed  Google Scholar 

  8. Theuer CP, de Virgilio C, Keese G, et al. Gastric adenocarcinoma in patients 40 years of age or younger. Am J Surg 1996; 172:473–6; discussion 476–7

    Article  PubMed  CAS  Google Scholar 

  9. Medina-Franco H, Heslin MJ, Cortes-Gonzalez R: Clinicopathological characteristics of gastric carcinoma in young and elderly patients: a comparative study. Ann Surg Oncol 2000; 7:515–9

    Article  PubMed  CAS  Google Scholar 

  10. Matley PJ, Dent DM, Madden MV, et al. Gastric carcinoma in young adults. Ann Surg 1988; 208:593–6

    Article  PubMed  CAS  Google Scholar 

  11. Bloss RS, Miller TA, Copeland EM. Carcinoma of the stomach in the young adult. Surg Gynecol Obstet 1980; 150:883–6

    PubMed  CAS  Google Scholar 

  12. Fujimoto S, Takahashi M, Ohkubo H, et al. Comparative clinicopathologic features of early gastric cancer in young and older patients. Surgery 1994; 115:516–20

    PubMed  CAS  Google Scholar 

  13. Santoro R, Carboni F, Lepiane P, et al. Clinicopathological features and prognosis of gastric cancer in young European adults. Br J Surg 2007; 94:737–42

    Article  PubMed  CAS  Google Scholar 

  14. Nakamura K, Ueyama T, Yao T, et al. Pathology and prognosis of gastric carcinoma. Findings in 10,000 patients who underwent primary gastrectomy. Cancer 1992; 70:1030–7

    Article  PubMed  CAS  Google Scholar 

  15. Siewert JR, Bottcher K, Stein HJ, et al. Relevant prognostic factors in gastric cancer: ten-year results of the German Gastric Cancer Study. Ann Surg 1998; 228:449–61

    Article  PubMed  CAS  Google Scholar 

  16. Llanos O, Butte JM, Crovari F, et al. Survival of young patients after gastrectomy for gastric cancer. World J Surg 2006; 30:17–20

    Article  PubMed  Google Scholar 

  17. Eguchi T, Fujii M, Takayama T. Mortality for gastric cancer in elderly patients. J Surg Oncol 2003; 84:132–6

    Article  PubMed  Google Scholar 

  18. Japanese Gastric Cancer Association. Japanese Classification of Gastric Carcinoma—2nd English edition. Gastric Cancer 1998; 1:10–24

    Article  PubMed  Google Scholar 

  19. Hosokawa O, Tsuda S, Kidani E, et al. Diagnosis of gastric cancer up to three years after negative upper gastrointestinal endoscopy. Endoscopy 1998; 30:669–74

    Article  PubMed  CAS  Google Scholar 

  20. Korean Gastric Cancer Association. Nationwide Gastric Cancer Report in Korea. J Korean Gastric Cancer Assoc 2002; 2:105–114

    Google Scholar 

  21. Maconi G, Kurihara H, Panizzo V, et al. Gastric cancer in young patients with no alarm symptoms: focus on delay in diagnosis, stage of neoplasm and survival. Scand J Gastroenterol 2003; 38:1249–55

    Article  PubMed  CAS  Google Scholar 

  22. Boldys H, Marek TA, Wanczura P, et al. Even young patients with no alarm symptoms should undergo endoscopy for earlier diagnosis of gastric cancer. Endoscopy 2003; 35:61–7

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, Yonsei University College of Medicine, Seoul 120–752, Korea

    Ji Fu Lai MD, Sungsoo Kim MD, Chen Li MD, Sung Jin Oh MD, Woo Jin Hyung MD, Won Hyuk Choi MD, Seung Ho Choi MD & Sung Hoon Noh MD

  2. Department of Surgical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, 310016, China

    Ji Fu Lai MD & Lin Bo Wang MD

  3. Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul 120–752, Korea

    Sungsoo Kim MD, Sung Jin Oh MD & Sung Hoon Noh MD

  4. Department of Surgery, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China

    Chen Li MD

  5. Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120–752, Korea

    Sung Hoon Noh MD

Authors
  1. Ji Fu Lai MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sungsoo Kim MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chen Li MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sung Jin Oh MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Woo Jin Hyung MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Won Hyuk Choi MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Seung Ho Choi MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Lin Bo Wang MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Sung Hoon Noh MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sung Hoon Noh MD.

Additional information

Ji Fu Lai and Sungsoo Kim contribute equally to this work.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lai, J.F., Kim, S., Li, C. et al. Clinicopathologic Characteristics and Prognosis for Young Gastric Adenocarcinoma Patients after Curative Resection. Ann Surg Oncol 15, 1464–1469 (2008). https://doi.org/10.1245/s10434-008-9809-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1245/s10434-008-9809-1

Keywords

Search

Navigation