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Antibacterial and Antioxidant Study of New Pharmaceutical Formulation of Didecyldimethylammonium Bromide Via Pharmaceutical Deep Eutectic Solvents (PDESs) Principle

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Abstract

Combination therapies have been studied by many researchers using different techniques and methods to solve some solid drug problems and improve more effective treatments for humans and animals. One of the more significant findings to emerge from this study is that the combination of pharmaceutical agents by using pharmaceutical deep eutectic solvents (PDESs) in order to produce dual action drugs and reduce the drug resistance. The major objective of this study was to investigate the dual functionality of drugs (antioxidant and antibacterial activity) via the principle of PDESs. The produced PDESs were characterized via different techniques, namely differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and UV-Vis spectrophotometry. We herein tested a panel of novel liquid formulations of didecyldimethylammonium bromide (DDMAB) against a selection of pathogenic bacteria, classifying their spectrum of activity against Gram-positive and Gram-negative bacteria. The current study found that the PDESs can be used to produce drugs with dual functionalities. The produced PDES from (ascorbic acid: DDMAB) exhibits stronger antibacterial activity against Gram-positive Staphyloccocus aureus and Staphyloccocus epidermidis than gram negatives. One of the most interesting PDESs studied in this research was that of DDMAB and ascorbic acid. This forms a eutectic which is far from the solid drugs issues and shows dual functionality like antibacterial and antioxidant activity. This study has found that there is a correlation between the molecular docking study and the biological activities of the combined drugs.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq

    Idrees B. Qader, Hiwa O. Ahmad & Hemn A. Qader

  2. Department of Pharmacy, College of Medicine, University of Kurdistan-Hawler, Erbil, Kurdistan region, Iraq

    Idrees B. Qader & Hiwa O. Ahmad

  3. Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq

    Aryan R. Ganjo

  4. Department of Medical Analysis, Faculty of Applied Science, Tishk International University, Erbil, Kurdistan Region, Iraq

    Aryan R. Ganjo

  5. Department of Pharmaceutics, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq

    Hewa A. Hamadameen

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Contributions

IBQ: project supervisor, first draft, and corrections. ARG: experimental, corrections, and writing first draft. HOA: writing the draft, experimental, revision, and corrections. HAQ has contributed in terms of literature review and communication. HAH: experimental and revision.

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Correspondence to Idrees B. Qader.

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Qader, I.B., Ganjo, A.R., Ahmad, H.O. et al. Antibacterial and Antioxidant Study of New Pharmaceutical Formulation of Didecyldimethylammonium Bromide Via Pharmaceutical Deep Eutectic Solvents (PDESs) Principle. AAPS PharmSciTech 25, 25 (2024). https://doi.org/10.1208/s12249-024-02739-4

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