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Exploiting Polymeric Films as a Multipurpose Drug Delivery System: a Review

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Abstract

Polymeric films are drug delivery systems that maintain contact with the delivery tissue and sustain a controlled release of therapeutic molecules. These systems allow a longer time of drug contact with the target site in the case of topical treatments and allow the controlled administration of drugs. They can be manufactured by various methods such as solvent casting, hot melt extrusion, electrospinning, and 3D bioprinting. Furthermore, they can employ various polymers, for example PVP, PVA, cellulose derivatives, chitosan, gelling gum, pectin, and alginate. Its versatility is also applicable to different routes of administration, as it can be administered to the skin, oral mucosa, vaginal canal, and eyeballs. All these factors allow numerous combinations to obtain a better treatment. This review focuses on exploring some possible ways to develop them and some particularities and advantages/disadvantages in each case. It also aims to show the versatility of these systems and the advantages and disadvantages in each case, as they bring the opportunity to develop different medicines to facilitate therapies for the most diverse purposes .

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Acknowledgements

All figures were made by Lorena Cararotto do Amaral. The professional English editing was done by Prof. Dr. Paulo Cesar Ribeiro Filho (University of São Paulo, FFLCH-USP).

Funding

This study was financed in part by the Coordenacão de Aperfeiçoamento Pessoal de Nível Superior, Brasil (CAPES), Finance Code 001, São Paulo Research Foundation–FAPESP (grant number 2019/00164–0), CNPq (Brasília, Brazil), and PACD-FCFAr-UNESP (Araraquara, Brazil).

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Authors and Affiliations

  1. Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University, Araraquara, São Paulo, Brazil

    Bruno Vincenzo Fiod Riccio, Amanda Letícia Polli Silvestre, Andreia Bagliotti Meneguin, Tais de Cassia Ribeiro & Marlus Chorilli

  2. Department of Pharmaceutical Sciences, Ponta Grossa State University, Ponta Grossa, Paraná, Brazil

    Ana Beatriz Klosowski & Priscileila Colerato Ferrari

Authors
  1. Bruno Vincenzo Fiod Riccio
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  2. Amanda Letícia Polli Silvestre
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  3. Andreia Bagliotti Meneguin
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  4. Tais de Cassia Ribeiro
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  5. Ana Beatriz Klosowski
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  6. Priscileila Colerato Ferrari
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  7. Marlus Chorilli
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Contributions

Conceptualization: Bruno Riccio, Amanda Silvestre, Andreia Meneguin, Franciele Baveloni, Tais Ribeiro, and Marlus Chorilli. Investigation: Bruno Riccio, Amanda Silvestre, Andreia Meneguin, Franciele Baveloni, and Tais Ribeiro. Resources: Marlus Chorilli. Writing—original draft preparation: Bruno Riccio, Amanda Silvestre, Andreia Meneguin, Franciele Baveloni, and Tais Ribeiro. Writing—review and editing: Priscileila Ferrari and Marlus Chorilli. Supervision: Andreia Meneguin, Priscileila Ferrari, and Marlus Chorilli. Project administration: Priscileila Ferrari and Marlus Chorilli.

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Correspondence to Bruno Vincenzo Fiod Riccio.

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Riccio, B.V.F., Silvestre, A.L.P., Meneguin, A.B. et al. Exploiting Polymeric Films as a Multipurpose Drug Delivery System: a Review. AAPS PharmSciTech 23, 269 (2022). https://doi.org/10.1208/s12249-022-02414-6

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